Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Sanghamitra Sahoo, PhD
Research Instructor
Thomas E. Starzl Biomedical Science Tower 200 Lothrop Street Room E1228-2B
Pittsburgh, PA 15261

Email:
sas279@pitt.edu
Phone: 412-648-2610


Education
BSc (Microbiology), Delhi University, India, 1996
MSc (Microbiology), Orissa University of Agriculture & Technology, India, 1998
PhD (Life Science), Utkal University, India, 2006


Research Areas
Receptor Pharmacology
Redox Pharmacology
Signal Transduction
Photo of Sanghamitra Sahoo, PhD

Dr. Sahoo’s research is focused on microRNA-mediated pathogenesis of cardiovascular diseases, particularly pulmonary hypertension. MicroRNAs (miRNAs or miRs) are small (~19-25 nucleotides), non-coding endogenous RNA molecules that negatively regulate the expression of proteins via post-transcriptional modifications. A single miR can regulate multiple targets simultaneous and several miRs may modulate the function of a protein. The objective of these studies is to advance our understanding of molecular and signaling mechanisms in pulmonary vascular endothelial and smooth muscle cells; primary cells involved in vascular remodeling of the pulmonary microcirculation. The outcomes from these studies will provide insights into newer therapeutic targets for the management of cardiovascular diseases.




Important Publications
Sahoo S, Meijles DN,  Al Ghouleh I, Tandon M, Cifuentes-Pagano E, Sembrat J, Rojas M, Goncharova E and Pagano PJ. MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 promotes smooth muscle cell phenotype switching in pulmonary rterial Hypertension. PLOS ONE 11, 2016.
Al Ghouleh IA, Meijles DN, Mutchler S, Zhang Q, Sahoo S, Gorelova A, Amaral JH, Rodríguez AI, Mamonova T, Song GJ, Bisello A, Friedman PA, Cifuentes-Pagano E and Pagano PJ. Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype. Proceedings of the National Academy of Sciences of the United States of America 11:E5308-E5317.
Keshava S, Sahoo S, Tucker TA, Idell S, Rao LVM and Pendurthi UR. Endothelial cell protein C receptor opposes mesothelioma growth driven by tissue factor. Cancer Res 73:3963-3973.
Ranayhossaini DJ, Rodríguez AI, Sahoo S, Chen BB, Mallampalli RK, Kelley EE, Csanyi G, Gladwin MT, Romero G and Pagano PJ. Selective recapitulation of conserved and nonconserved regions of putative noxa1 protein activation domain confers isoform-specific inhibition of nox1 oxidase and attenuation of endothelial cell migration. Journal of Biological Chemistry 288:36437-36450.
Sen P, Sahoo S* (co-first author), Pendurthi UR and Rao LVM. Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor. J Biol Chem 285:20410-20420.
Sahoo S, Singh A, Himabindu G, Banerjee J, Sitalaximi T, Gaikwad S, Trivedi R, Endicott P, Kivisild T, Metspalu M, Villems R and Kashyap VK. A prehistory of Indian Y chromosomes: evaluating demic diffusion scenarios. Proc Natl Acad Sci U S A 103:843-848.




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