Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Jerry Gebhart, PhD
Professor, Anesthesiology
W1444 Biomedical Science Tower
200 Lothrop Street, Pittsburgh, PA 15261

Email:
gfg2@pitt.edu
Phone: 412-383-5910


Education

BS, University of Illinois, College of Pharmacy, 1967.
PhD (Pharmacology), University of Iowa, 1971.
Post-doc (Neurophysiology), University of Montreal, 1971-73.



Research Areas
Neuropharmacology
Photo of Jerry Gebhart, PhD

Acute or chronic pain that requires medical attention affects an estimated 45% of Americans annually. Despite its importance and often compelling insistence, mechanisms of pain and of pain control are incompletely understood. A principal focus of the laboratory is investigation of the mechanisms of enhanced sensitivity to pain, termed hypersensitivity or hyperalgesia (a plastic change in the nervous system), that develops following tissue injury. A complementary research focus is study of the organization and operation of endogenous systems of pain control and their contribution to chronic pain states.

 

Experimental approaches include: single sensory nerve fiber recording, patch clamp recording from identified nerve cell bodies in dorsal root ganglion neurons, and procedures for quantification or localization of peptides, G protein-coupled receptors, immediate early genes and ion channels that play an important role in pain.

 





Important Publications
Feng B, Brumovsky PR, Gebhart GF. Differential roles of stretch-sensitive pelvic nerve afferents innervating mouse distl colon and rectum. Am J Physiol Gastrointest Liver Physiol. 210 Mar;298(3):G402-9. Epub 2010 Jan 14.
Chen X, Molliver DC, Gebhart GF. The P2Y2 receptor sensitizes mouse bladder sensory neurons and facilitates purinergic currents. J Neurosci. 2010 Feb 10;30(6):2365-72.
Chen X, Gebhart GF. Differential purinergic signaling in bladder sinsory neurons of naive and bladder-inflamed mice. Pain. 2010 mar;148(3):462-72. Epub 2009 Dec 31.
Brumovsky PR, Gebhart GF. Visceral organ cross-sensitization - an integrated perspective. Auton Neurosci. 2010 Feb 16;153(1-2):106-15. Epub 2009 Aug 12.




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