Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Roderick J. O'Sullivan, PhD
Assistant Professor
Suite 2.6d Hillman Cancer Center 5117 Centre Avenue
Pittsburgh, PA 15213

Email:
osullivanr@upmc.edu
Phone: 412-623-7763

Fax: 412-623-7761


Education

Trinity College Dublin, Dublin, Ireland, 1998-2002

Institute for Molecular Pathology, Vienna, Austria, 2002-2006

The Salk Institute for Biological Studies, La Jolla, CA, 2006-2014



Research Areas
Cancer Pharmacology
DNA Repair
Photo of Roderick J. O'Sullivan, PhD

O'Sullivan Lab Website

The O’Sullivan lab at the Hillman Cancer Center conducts research into proteins that alter the structural and epigenetic functions of human telomeres. Telomeres are structures at the ends of chromosomes – the integrity of telomeres is an important factor in maintaining genome stability to prevent cancer and accelerated aging. Current efforts in the lab relate to deciphering the relationship between the regulation between chromatin structure and telomere function in the Alternative Lengthening of Telomeres pathway.





Important Publications
O’Sullivan RJ, Arnoult N, Lackner DH, Oganesian L, Haggblom C, Corpet A, Almounzi G and Karlseder J. Rapid induction of the alternative lengthening of telomeres pathway by depletion of the histone chaperone ASF1. Nat Struct Mol Biol 21:167-174, 2013.
O’Sullivan R and Karlseder J. The great unravelling: Chromatin as a modulator of the aging process. Trends Biochem Sci 37:466-476, 2012.
Corpet A, De Koning L, Toedling J, Savignoni A, Berger F, Lemaitre C, O’Sullivan RJ, Karlseder J, Barrilot E, Asselain B, Sastre-Garau X and Almouzni G. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. EMBO J 30:480-493, 2011.
Flynn RL, Centore RC, O’Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J and Zou L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature 471:532-526. 2011. 
O'Sullivan RJ and Karlseder J. Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol 11:171-81, 2010.
O’Sullivan RJ, Kubicek S, Schreiber SL and Karlseder J.  Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat Struct Mol Biol 17:1218-1226, 2010.
Kubicek S, O'Sullivan RJ, August EM, Hickey E, Mechtler K, Rea S, Farina P, Homon C, Kelly T and Jenuwein T. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell 25:473-481, 2007.

STUDENT NEWS


UPCOMING EVENTS
11/27/2017 8:30 AM Molecular Pharmacology Journal Club
Lloyd Harvey


11/30/2017 12:00 PM Pharmacology & Chemical Biology Seminar Series
Jeffrey L. Brodsky, Ph.D.


12/4/2017 8:30 AM Molecular Pharmacology Journal Club
Andrew Lamade


Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Molecular Pharmacology Graduate Program Ranked #2 in Faculty Scholarly Productivity Index


Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty consecutive years




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