Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Lawrence Kane, PhD
Associate Professor, Immunology
E1056 Biomedical Science Tower
Pittsburgh, PA 15261

Phone: 412-648-8947

Fax: 412-383-8098


BS (Biology), Boston College, 1988.
PhD (Immunology), Univ. of Calif., San Diego, 1996.
Post-Doc, University of California, San Francisco, 1996-2000.
Adjunct Faculty, University of California, San Francisco 2000-2003

Research Areas
Signal Transduction
Photo of Lawrence Kane, PhD

My lab is currently pursuing several projects:


1. The role of TIM family molecules in T cell activation and differentiation

This project currently involves the study of TIM-1, a novel protein of the T cell immunoglobulin and mucin domain family. We have found that TIM-1 can provide a co-stimulatory signal, along with the TCR, that affects T cell activation and differentiation. We are trying to determine what signaling pathways are activated by TIM-1 as well as performing structure/function studies to determine how TIM-1 couples to these pathways.


2. Activation of NF-kB by the Akt kinase

We found that Akt can induce NF-kB-dependent transcription, in cooperation with signals from PKC. We are currently working to identify direct targets of Akt in this pathway, as well as its consequences for T cell activation and CD28 co-stimulation. One target that we have already identified is a MAP3K family member called Cot, or Tpl-2. We have found that Akt can phosphorylate Cot and modulate its function. We are currently trying to determine how phosphorylation of Cot affects its function.

Important Publications
Narayan P, Holt B, Tosti R and Kane LP. (2006) CARMA1 is required for Akt-mediated NF-KB activation in T cells. Mol Cell Biol. 26:2327.
Knickelbein J, de Souza AJ, Narayan P, Tosti R and Kane LP. (2006) Cutting Edge: Inhibition of T cell activation by TIM-2. J. Immunol. 177:4966.

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