Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Richard Steinman, MD
Associate Professor, Medicine
2.18 Hillman Cancer Center
Pittsburgh, PA 15213

Phone: 412-623-3237

Fax: 412-623-7778


B.S. (Chemistry), Haverford College, 1978. M.D. (Medicine), University of Pennsylvania, 1987. Ph.D. (Biochemistry), University of Pennsylvania, 1988.

Research Areas
Cancer Pharmacology
Photo of Richard Steinman, MD


Differentiation Carcinogenesis

Health literacy

Minority education

Dr. Steinman's research focuses on dissection of the tumor microenvironment. His approach includes the development of a preclinical tool to enable fluorescent labeling of bystander cells along the path taken through the body by cancer; this is expected to make it possible for each normal cell that encountered the cancer to be isolated and characterized for collaborating signals. Additional work exploits real-time labeling of the transcription of specific cells of interest in complex cellular mixtures and environments without cell separation in order to uncover and dissect the impact of signaling pathways on tumor-stromal co-evolution. He has established a conditional transgenic mouse model to facilitate these studies. The progress of this work is bolstered by Dr. Steinman's expertise in analyzing signals that control cancer cell behavior and in identifying both paracrine and juxtacrine signaling pathways controlling the activity of the Stat3 protein. His lab also is studying the effects of fibrosis on cancer metastasis.

Important Publications
Steinman RA, Wang Q, Gasparetto M, Robinson LJ, Liu X, Lenzner DE, Hou J, Smith C, Wang Q. Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice. Int J Cancer. 2013 Apr 15;132(8):1741-50.
Steinman RA, Robinson AR, Feghali-Bostwick CA. Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts. PLoS One 2012;7(11):e48560.
Sharma R, Wang Y, Zhoi P, Steinman RA and Wang Q. An essential role of RNA editing enzyme ADAR1 in mouse skin. J Dermatol Sci. 2011 Oct.64(1):70-2(2011)
Steinman RA, Wang Q. ADAR1 isoform involvement in embryonic lethality. Proc Natl Acad Sci USA. 2011 Jun 14:108(24):E199. Epub 2011 May 18.
S.H. Leuba and R.A. Steinman 2011 How to think like a single molecule: obtaining quantitative measurements on single DNA molecules and chromatin fibers in Biophysics of Protein-DNA Interactions. M.C. Williams and L.J. Maher, III, Eds. Springer, NY pp. 307-323.
Steinman RA. Cancer therapeutics: time to swim downstream? Oncologist 2011;16(10):1479-80.
Andraos-Selim C, Modzelewski RA and Steinman RA. Inter-institutional development of a poster-based cancer biology learning tool. J. Cancer Educ. 2010 Sep.25(3):413-7(2010). 
Steinman RA. mRNA stability control: A clandestine force in normal and malignant hematopoiesis. Leukemia 21(6):1158-1171, 2007.
Duensing A, L Ghanem, RA Steinman, Y Liu and S Duensing.  p21Waf1/Cip1 deficiency stimulates centriole overduplication. Cell Cycle 24:2899-2902, 2006.
Ghanem L and RA Steinman.  p21Waf1 inhibits granulocytic differentiation of 32Dcl3 cells. Leukemia Research 30:1285-1292, 2006.
Ghanem L and RA Steinman.  A proapoptotic function of p21 in differentiating granulocytes. Leukemia Research 29:1315-1323, 2005.
Steinman RA, Brufsky AM, Oesterreich S. Zoledronic acid effectiveness angainst breast cancer metastases - a role for estrogen in the microenvironment? Breast Cancer Res. 2012 Sep 21;14(5)213 [Epub ahead of print]

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