Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Thomas Kleyman, MD
Professor of Medicine, Cell Biology, Physiology, Chief, Renal-Electrolyte Division
A919 Scaife Hall
Pittsburgh, PA 15261

Phone: 412-647-3121

Fax: 412-648-9166

BS, Syracuse University, 1973.
MD, Washington University, 1978.
Photo of Thomas Kleyman, MD

Important Publications
Bruns JB, MD Carattino, S Sheng, AB Maarouf, OA Weisz, JM Pilewski, RP Hughey and TR Kleyman. Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma subunit. J Biol Chem 282:6153-6160, 2007.
Kashlan OB, AB Maarouf, C Kussius, RM Denshaw, KM Blumenthal and TR Kleyman. Distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel. J Biol Chem 281:30455-30462, 2006.
Carattin, MD, S Sheng, JB Bruns, JM Pilewski, RP Hughey and TR Kleyman. The epithelial Na+ channel is blocked by a peptide derived from proteolytic processing of its alpha subunit. J Biol Chem 281:18901-18907, 2006.
Morimoto T, W Liu, C Woda, MD Carattino, Y Wei, RP Hughey, G Apodaca, LM Satlin and TR Kleyman. Mechanism underlying flow-stimulation of sodium absorption in the mammalian collecting duct. Am J Physiol 291:F663-F669, 2006.
Sheng S, CJ Perry, OB Kashlan and TR Kleyman. Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels. J Biol Chem 280:8513-8522, 2005.

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