Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Current Students' Publications

Victoria Veroli

Tucci P., Veroli V., Señorale M., Marín M. “Escherichia coli: The Leading Model for the Production of Recombinant Proteins” Microbial Models: From Environmental to Industrial Sustainability. Ed. Susana Castro-Sowinski. Springer. 2016. 119-147. Print. 



Munguía B., Teixeira R., Veroli V., Melian E., Saldaña J., Minteguiaga M., Señorale M., Marín M., Domínguez L. “Purification of native M. vogae and H. contortus tubulin by TOG affinity chromatography” Experimental Parasitology. 182:37-44, 2017.




Alex White

Dube, S.; Dube, H.; Green, N.B.; Larsen, E.M.; White, A.; et al. In vivo delivery and activation of masked fluorogenic hydrolase substrates by endogenous hydrolases in C. elegans. ChemBioChem. 2017 Sep 19; 18(18): 1807-1813. doi: 10.1002/cbic.201700278. Epub 2017 Aug 7.PMCID:PMC5605452




Atinuke Dosunmu-Ogunbi

Kulkarni, S., Dolezal, J. M., Wang, H., Jackson, L., Lu, J., Frodey, B. P., Dosunmu-Ogunbi A, Li Y., Fromherz M., Kang A., Santana-Santos L., Benos P., Prochownik, E. V. (2017). Ribosomopathy-like properties of murine and human cancers. PLoS ONE12(8)PMCID: PMC5562309
 



Mohan, S., Das, D., Bauer, R. J., Heroux, A., Zalewski, J. K., Heber, S., Dosunmu-Ogunbi A.M., Trakselis M., Hildebrand J., VanDemark, A. P. (2013). Structure of a Highly Conserved Domain of Rock1 Required for Shroom-Mediated Regulation of Cell Morphology. PLoS ONE8(12)PMCID: PMC3857177




Lloyd Harvey

Harvey LD, Chan SY. Emerging metabolic therapies in pulmonary arterial hypertension. J Clin Med. 2017;6(4). PubMed PMID: 28375184; PubMed Central PMCID: PMC5406775.



Harvey L, Yin Y, Attarwala IY, Begum G, Deng J, Yan HQ, Dixon CE, Sun D. Administration of DHA reduces ER stress-associated inflammation and alters microglial or macrophage activation in traumatic brain injury. ASN Neuro. 2015;7(6). PubMed PMID: 26685193; PubMed Central PMCID: PMC4710127.



Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree JL, Harvey L, Sun D, Hubner CA, Cull-Candy SG, Farrant M, Gallo V. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nature Neuroscience. 2015;18(5):674-82. Epub 2015/03/31. doi: 10.1038/nn.3990. PubMed PMID: 25821912; PubMed Central PMCID: PMC4459267.



Begum G*, Harvey L*, Dixon CE, Sun D. ER stress and effects of DHA as an ER stress inhibitor. Translational Stroke Research. 2013;4(6):635-42. Epub 2013/12/11. doi: 10.1007/s12975-013-0282-1. PubMed PMID: 24323417; PubMed Central PMCID: PMC3864671. *denotes co-first authorship.




Thong Luong

Hardeman KN, Peng C, Paudel BB, Meyer CT, Luong T, Tyson DR, Young JD, Quaranta V, Fessel JP. Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition. Sci Rep. 2017 Feb 16;7:42604. doi: 10.1038/srep42604. PubMed PMID: 28205616; PubMed Central PMCID: PMC5311997.



Egnatchik RA, Brittain EL, Shah AT, Fares WH, Ford HJ, Monahan K, Kang CJ, Kocurek EG, Zhu S, Luong T, Nguyen TT, Hysinger E, Austin ED, Skala MC, Young JD, Roberts LJ 2nd, Hemnes AR, West J, Fessel JP. Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension. Pulm Circ. 2017 Feb 1;7(1):186-199. doi: 10.1086/690236. eCollection 2017 Mar. PubMed PMID: 28680578; PubMed Central PMCID: PMC5448547.




Nicholas Todd

Huang, Y., Todd, N. & Thathiah, A. The role of GPCRs in neurodegenerative diseases: avenues for therapeutic intervention. Curr. Opin. Pharmacol. 32, 96–110 (2017).




Emily Bossart

Nayak SR, Harrington E, Boone D, Hartmaier R, Chen J, Pathiraja TN, Cooper KL, Fine JL, Sanfilippo J, Davidson NE, Lee AV, Dabbs D, Oesterreich S. A Role for Histone H2B Variants in Endocrine-Resistant Breast Cancer. Horm Cancer. 2015 Dec;6(5-6):214-224. PMID: 26113056  PMCID:  PMC4807402


Katz TA, Vasilatos SN, Harrington E, Oesterreich S, Davidson NE, Huang Y. Inhibition of histone demethylase LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells. Breast Cancer Res Treat. 2014 Jul;146(1):99-108. PMID: 24924415    [PubMed - indexed for MEDLINE]
 


Stephanie Mutchler

Mutchler SM, Straub AC. Compartmentalized nitric oxide signaling in the resistance vasculature. Nitric Oxide. 2015 May 28.
pii:S1089-8603(15)00218-9. doi: 10.1016/j.niox.2015.05.003. PMID: 26028569



Rahaman MM, Reinders FG, Koes D, Nguyen AT, Mutchler SM, Sparacino-Watkins C, Alvarez RA, Miller MP, Cheng D, Chen BB, Jackson EK, Camacho CJ, Straub AC. Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.JBC 2015 PMID:26001785
 

Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE. A molecular signature in the pannexin1 intracellular loop confers channel activation by the alpha1 adrenoreceptor in smooth muscle cells. Sci Signal. (2015) 8; ra17. PMID: 25690012 [PubMed - in process]



Straub AC, Butcher J, Billaud M, Mutchler S, Artamonov M, Nguyen A, Johnson T, Best A, Miller M, Palmer L, Columbus L, Somlyo A, Le T, Isakson B. Hemoglobin alpha/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction. ATVB (2014) 34; 2594-2600. PMID: 25278292 [PubMed - in process] PMCID: PMC4239174 [Available on 2015-12-01]



Billaud M, Lohman AW, Johnstone SR, Biwer LA, Mutchler SM, Isakson BE: Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacol Rev (2014) 66; 513-569. PMID: 24671377 [PubMed - indexed for MEDLINE] PMCID: PMC3973613 [Available on 2015-04-01]



Cechova S, Zeng Q, Billaud M, Mutchler S, Rudy CK, Straub AC, Chi L, Chan FR, Hu J, Griffiths R, Howell NL, Madsen K, Boye J, Palmer LA, Carey RM, Sung SJ, Malakauskas SM, Isakson BE, Le TH: Loss of collectrin, an ACE homologue, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction. Circulation (2013) 128; 1770-1780. PMID: 24048198 [PubMed - indexed for MEDLINE]



Looft-Wilson R, Todd SE, Araj CA, Mutchler SM, Raphael Goodell CA: Alpha1-adrenergic-mediated eNOS phosphorylation in intact arteries. Vascul Pharmacol (2013) 58; 112-117. PMID: 22982055 PMCID: PMC3534816




Braulio Bonilla

Rojas JJ, Sampath P, Bonilla B, Ashley A, Hou W, Byrd D, Thorne SH.Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies. Cell Rep. 2016 Apr 12;15(2):264-73. PMID:  27050526 PMCID: PMC4830920

 



Alison Nagle

Baumgarner BL, Nagle AM, Quinn MR, Farmer AE, Kinsey ST. Dietary supplementation of b-guanidinopropionic acid (bGPA) reduces whole-body and skeletal muscle growth in young CD-1 mice. Mol Cell Biochem. 2015. PMID: 25701355



Nyla Naim

Peters S., Naim N., Nelson D., Mosier A.P., Cady N., Larsen M. Biocompatible tissue scaffold compliance promotes salivary gland morphogenesis and differentiation. Tissue Eng. 2014 Jun;20(11-12):1632-42 doi: 10.1089/ten.TEA.2013.0515.  PMID: 24410370 PMCID: PMC4029047




Vera Procaccia

Procaccia V, Nakayama H, Shimizu A, Klagsbrun M.Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility. Biochem Biophys Res Commun. 2014 May 30;448(2):134-8. doi: 10.1016/j.bbrc.2014.04.063. Epub 2014 Apr 20. PMID: 24759231 PMCID: PMC4068341



STUDENT NEWS


UPCOMING EVENTS
11/27/2017 8:30 AM Molecular Pharmacology Journal Club
Lloyd Harvey


11/30/2017 12:00 PM Pharmacology & Chemical Biology Seminar Series
Jeffrey L. Brodsky, Ph.D.


12/4/2017 8:30 AM Molecular Pharmacology Journal Club
Andrew Lamade


Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Molecular Pharmacology Graduate Program Ranked #2 in Faculty Scholarly Productivity Index


Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty consecutive years




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