Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Pharmacology & Chemical Biology Seminar Series
Thursday, December 13, 2018 - 12:00 PM

“Pharmacology of DNA damage signaling in the immune system”

Chris Bakkenist, Ph.D.
Associate Professor
Radiation Oncology
UPMC Hillman Cancer Center

ATM and ATR are DNA damage signaling kinases that regulate DNA replication and homologous recombination repair. Pharmacologic inhibitors of ATM and ATR kinase activity have been developed and these are predicted to increase the efficacy of genotoxic chemotherapy. A primary focus of the Bakkenist laboratory is to determine the mechanistic consequences of ATM and ATR kinase inhibition. Recently, the laboratory identified an ATR kinase-dependent mechanism that inhibits dormant origin firing in mammalian cells. This is a fundamental mechanism of genome stability that evolved with chromosomes that contain more than one origin.

Thomas E. Starzl Biomedical Science Tower
1395 Conference Room
203 Lothrop Street
Pittsburgh PA 15213
Melanie McClain

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