Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Edwin K. Jackson, PhD
Professor
Bridgeside Point Building, Office: Room 514; Labs: Rooms 520 and 522
100 Technology Drive, Pittsburgh, PA 15219

Email:
edj@pitt.edu
Phone: 412-648-1505

Fax: 412-624-5070


Education

BS (Pharmacy), University of Texas at Austin, 1976
PhD (Pharmacology), University of Texas Southwestern Medical Center, 1979
Postdoctoral Fellow (Clinical Pharmacology), Vanderbilt University, 1979-1981



Research Areas
Purine Pharmacology
Cardiovascular and Renal Pharmacology
Metabolic Syndrome Pharmacology
Neuropharmacology
Pharmacology of Cell and Organ Systems
Photo of Edwin K. Jackson, PhD

Purine Pharmacology:  Adenosine is an endogenous purine that regulates most physiological systems.  We are investigating (using a variety of molecular, analytical, cellular and physiological tools and using several strains of genetically modified animals, as well as conducting studies in patients): 1) the production of adenosine from 3’,5’-cAMP and 2’,3’-cAMP (the cAMP-adenosine pathways; see Figure 1); 2) the modulation of adenosine levels by guanosine;3) the roles of adenosine in regulating the sympathetic nervous system, heart, vascular system, kidneys, bladder, brain and immune system;4)  the effects of adenosine on cardiac fibroblasts, vascular smooth muscle cells, vascular endothelial cells, glomerular mesangial cells, renal epithelial cells, T cells and B cells; 5) the role of exosomes in adenosine biochemistry; 6) how to modulate the adenosine system with drugs to treat cardiovascular and renal diseases, traumatic brain injury, cancer and HIV infected patients.
Figure 1

 
Cardiovascular and Renal Pharmacology:  Our recent studies indicate that NPY1-36 (a peptide released from sympathetic nerves) and PYY1-36 (a peptide released from the intestines) trigger proliferation of and extracellular matrix production by preglomerular vascular smooth muscle cells (PGVSMCs) and glomerular mesangial cells (GMCs) in kidneys from genetically-hypertensive animals, a phenomenon mediated via Y1 receptors and that involves signaling by RACK1 (receptor for activated C kinase 1).  Dipeptidyl peptidase IV (DPPIV) metabolizes NPY1-36 and PYY1-36 (Y1 receptor agonists) to NPY3-36 and PYY3-36 (inactive at Y1 receptors).  We are investigating whether a new class of antidiabetic drugs (DPPIV inhibitors) may adversely affect the kidneys of hypertensive subjects by preventing the conversion of PYY1-36 and NPY1-36 to less active metabolites and thereby promoting inappropriate cell proliferation and extracellular matrix production (see Figure 2). 

Figure 2




Important Publications
Jackson EK and Z Mi.  In Vivo cardiovascular pharmacology of 2’,3’-cAMP, 2’-AMP, and 3’-AMP in the rat. Journal of Pharmacology and Experimental Therapeutics (in press), 2013.
Verrier JD, TC Jackson, DG Gillespie, K Janesko-Feldman, R Bansal, A-K Nave, PM Kochanek and EK Jackson.  Oligodendrocyte expressed CNPase is essential to the extracellular 2’,3’-cAMP-adenosine pathway. GLIA (in press), 2013.
Saze Z, PJ Schuler, C-S Hong, D Cheng, EK Jackson and TL Whiteside.  Adenosine production by human B cells and B cell-mediated suppression of activated T cells. Blood (in press), 2013.
Jackson EK, D Cheng, TC Jackson, JD Verrier and DG Gillespie. Extracellular guanosine regulates extracellular adenosine levels.  American Journal of Physiology-Cell Physiology 304: C406-C421, 2013. 
Cheng D, X Zhu, GD Gillespie and EK Jackson. Role of RACK1 in the differential proliferative effects of neuropeptide Y1-36 and peptide YY1-36 in SHR versus WKY preglomerular vascular smooth muscle cells.  American Journal of Physiology-Renal Physiology 304: F770-F780, 2013. 
Jackson EK and DG Gillespie.  Extracellular 2’,3’-cAMP-adenosine pathway in proximal tubular,  thick ascending limb and collecting duct epithelial cells.   American Journal of Physiology-Renal Physiology 304: F49-F55, 2013. 
Jackson EK, D Cheng, SP Tofovic and Z Mi. Endogenous adenosine contributes to renal sympathetic neurotransmission via postjunctional A1-receptor-mediated coincident signaling.  American Journal of Physiology – Renal Physiology 302: F466-FF76, 2012.
Verrier JD, TC Jackson, PM Kochanek and Jackson EK. The brain in vivo expresses the 2’,3’-cAMP-adenosine pathway.  Journal of Neurochemistry 122: 115-125, 2012. 
Jackson EK, SJ Kochanek and DG Gillespie.  Dipeptidyl peptidase IV regulates proliferation of preglomerular vascular smooth muscle and mesangial cells.  Hypertension 60: 757-764, 2012.
Jackson EK and DG Gillespie. Extracellular 2’,3’-cAMP and 3’,5’-cAMP stimulate proliferation of preglomerular vascular endothelial cells and renal epithelial cells.  American Journal of Physiology – Renal Physiology 303: F954-F962, 2012. 




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