Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Christopher Bakkenist, PhD
Associate Professor, Radiation Oncology
Hillman Cancer Center 2.6
5117 Centre Avenue, Pittsburgh, PA 15232

Phone: 412-623-7765

Fax: 412-623-7761


BSc (Hons), Biochemistry/Chemistry, University of Liverpool, UK, 1989. PhD Imperial College, University of London, UK, 1994. Postdoctoral Fellow, St. Jude Children's Research Hospital, Memphis, TN, 1999-2005.

Research Areas
Cancer Pharmacology
DNA Repair
Photo of Christopher Bakkenist, PhD

Important Publications
Choi S, Srivas R, Fu KY, Hood BL, Dost B, Gibson GA, Watkins SC, Van Houten B, Bandeira N, Conrads TP, Ideker T and Bakkenist CJ.  (2012) Quantitative proteomics reveals ATM kinase-dependent exchange in DNA damage response complexes.  Journal of Proteome Research, advance online publication
Gamper AM, Choi S, Matsumoto M, Banerjee D, Tomkinson AE and Bakkenist CJ.  (2012)  ATM physically and functionally interacts with PCNA to regulate DNA synthesis.  Journal of Biological Chemistry 287:12445-12454.
Choi S, Toledo LI, Fernandez-Capetillo O and Bakkenist CJ.  (2011)  CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.  DNA Repair 10:1000-1001
White JS, Yue N, Hu J, Bakkenist CJ.  (2011)  The ATM kinase signaling induced by the low-energy ß-particles emitted by 33P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic ß-particles emitted by 32P.  Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 708, 28-36

Choi S, Gamper A, White JS, Bakkenist CJ.  (2010)  Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle 9: 4052-4057

White JS, Choi S, Bakkenist CJ.  (2010)  Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.  Science Signaling 3: ra44

Bakkenist CJ, Kastan MB.  (2004)  Initiating Cellular Stress Responses. Cell 118: 9-17

Bakkenist CJ, Kastan MB.  (2003)  DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.  Nature 421: 499-506


4/23/2018 12:00 AM Molecular Pharmacology Journal Club
Victoria Veroli

4/26/2018 12:00 PM Pharmacology & Chemical Biology Seminar Series
Roger K. Sunahara, Ph.D.

5/17/2018 12:00 PM Joint Pharmacology & Chemical Biology/Neurobiology Seminar
Shiva Tyagarajan, Ph.D.

Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty two consecutive years

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