Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Michael J. Palladino, PhD
Professor & Vice Chair, Academics
7042 Biomedical Science Tower 3
3501 Fifth Ave. Pittsburgh, PA 15260

Email:
mjp44@pitt.edu
Phone: 412-383-5900

Fax: 412-648-7029


Education

BS (Biology), Trinity College, 1997
PhD (Genetics – Biomedical Science), University of Connecticut Health Center, 2000
Postdoctoral Fellow (Neurobiology), University of Wisconsin—Madison, 2003



Research Areas
Drug Discovery
Neuropharmacology
Redox Pharmacology
Metabolic Syndrome Pharmacology
Pharmacology of Cell and Organ Systems
Photo of Michael J. Palladino, PhD

The Palladino lab uses Drosophila (the fruit fly) as a genetic model system, as well as mice and human cell culture to study progressive neurological and neuromuscular disorders. We are currently focusing on elucidating the mechanism by which mutations affecting Na/K ATPase, triose phosphate isomerase (TPI), and ATP6 function result in RDP (rapid-onset dystonia parkinsonism), glycolytic enzymopthy, and mitochondrial encephalomyopathy, respectively. Our research program is directed toward four main goals 1) discovering and characterizing novel pathways that cause progressive disease, 2) understanding the physiological, cellular and molecular dysfunction that causes dysfunction in vivo, 3) understanding the molecular basis of progressive diseases, and 4) using our animal model system to identify novel therapeutic approaches.





Important Publications
Hrizo SL and MJ Palladino.  Hsp70 and Hsp90 mediate proteasomal degradation of TPIsugarkill that underlies pathogenesis.  Neurobiology of Disease 40:676-683, 2010.
Palladino MJ.  Modeling mitochondrial encephalomyopathy in Drosophila.  Neurobiology of Disease 40:40-45, 2010.
Ashmore LJ, SL Hrizo, SM Paul, W Van Voorhies, GJ Beitel and MJ Palladino.  Novel mutations affecting the NA,K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity.  Human Genetics 126:431-447, 2009.
Celotto AM, AC Frank, JL Seigle and MJ Palladino. Drosophila model of human inherited TPI deficiency glycolytic enzymopathy. Genetics 174:1237-1246, 2006.
Celotto AM, AC Frank, SW McGrath, TJ Fergestad, WA Van Voorhies, K Buttle, CA Mannella and MJ Palladino. Mitochondrial encephalomyopathies in drosophila. Journal of Neuroscience 26(3):810-820, 2006.
Palladino MJ, JE Bower, R Kreber and Barry Ganetzky. Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants. Journal of Neuroscience 23(4):1276-1286, 2003.
Palladino MJ, TJ Hadley and B Ganetzky. Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila.  Genetics 161(3):1197-1208, 2002.
Palladino MJ, LP Keegan, MA O’Connell and RA Reenan. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell 102(4):437-449, 2000.




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