Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Stephanie Mutchler
Predoctoral Fellow
Email
smm226@pitt.edu

Education

BA/BS/AB, Kinesiology and Health Science, College of William & Mary, 2012



Funding Source
William C. de Groat Neuropharmacology Department Fellowship


Faculty Mentor
Thomas Kleyman, MD
A919 Scaife Hall
Photo of Stephanie Mutchler



Publications/Abstracts
Mutchler SM, Straub AC. Compartmentalized nitric oxide signaling in the resistance vasculature. Nitric Oxide. 2015 May 28.
pii:S1089-8603(15)00218-9. doi: 10.1016/j.niox.2015.05.003. PMID: 26028569

Rahaman MM, Reinders FG, Koes D, Nguyen AT, Mutchler SM, Sparacino-Watkins C, Alvarez RA, Miller MP, Cheng D, Chen BB, Jackson EK, Camacho CJ, Straub AC. Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.JBC 2015 PMID:26001785
 
Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE. A molecular signature in the pannexin1 intracellular loop confers channel activation by the alpha1 adrenoreceptor in smooth muscle cells. Sci Signal. (2015) 8; ra17. PMID: 25690012 [PubMed - in process]

Straub AC, Butcher J, Billaud M, Mutchler S, Artamonov M, Nguyen A, Johnson T, Best A, Miller M, Palmer L, Columbus L, Somlyo A, Le T, Isakson B. Hemoglobin alpha/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction. ATVB (2014) 34; 2594-2600. PMID: 25278292 [PubMed - in process] PMCID: PMC4239174 [Available on 2015-12-01]

Billaud M, Lohman AW, Johnstone SR, Biwer LA, Mutchler SM, Isakson BE: Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacol Rev (2014) 66; 513-569. PMID: 24671377 [PubMed - indexed for MEDLINE] PMCID: PMC3973613 [Available on 2015-04-01]

Cechova S, Zeng Q, Billaud M, Mutchler S, Rudy CK, Straub AC, Chi L, Chan FR, Hu J, Griffiths R, Howell NL, Madsen K, Boye J, Palmer LA, Carey RM, Sung SJ, Malakauskas SM, Isakson BE, Le TH: Loss of collectrin, an ACE homologue, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction. Circulation (2013) 128; 1770-1780. PMID: 24048198 [PubMed - indexed for MEDLINE]

Looft-Wilson R, Todd SE, Araj CA, Mutchler SM, Raphael Goodell CA: Alpha1-adrenergic-mediated eNOS phosphorylation in intact arteries. Vascul Pharmacol (2013) 58; 112-117. PMID: 22982055 PMCID: PMC3534816

STUDENT NEWS


UPCOMING EVENTS
11/27/2017 8:30 AM Molecular Pharmacology Journal Club
Lloyd Harvey


11/30/2017 12:00 PM Pharmacology & Chemical Biology Seminar Series
Jeffrey L. Brodsky, Ph.D.


12/4/2017 8:30 AM Molecular Pharmacology Journal Club
Andrew Lamade


Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Molecular Pharmacology Graduate Program Ranked #2 in Faculty Scholarly Productivity Index


Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty consecutive years




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