Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Pharmacology & Chemical Biology Seminar Series
Thursday, January 24, 2019 - 12:00 PM

"EGF receptor endocytosis and signaling in vitro and in vivo: Quantity transits into quality”

Initial attempts to analyze the endocytosis and signaling of the EGF receptor in vivo in mouse tumor xenografts will be described. I will also describe how we are using a combination of endogenous protein tagging by gene-editing, live-cell imaging and quantitative mass-spectrometry to study the spatiotemporal regulation of EGFR signaling to MAP kinases and generate computational models of this signaling process.
 

Alexander Sorkin, PhD
Richard Beatty Mellon Professor and Chair
Department of Cell Biology
University of Pittsburgh

Location:
Thomas E. Starzl Biomedical Science Tower
1395 Conference Room
203 Lothrop Street
Pittsburgh PA 15213
Contact:
Melanie McClain
4123788417
mmcclain@pitt.edu

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