Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Drug Discovery
Drug Discovery is an emerging pharmacological science that seeks to identify novel small molecule probes and to understand at a molecular level how compounds affect macromolecular process. Cell-based, in vitro mix-and-read, and whole organism assays suitable for rapid or high throughput analysis are being designed and implemented by members of the Molecular Pharmacology Program. Current molecular targets include Gprotein coupled receptors, vanilloid receptors, cathepsins, apoptosis-inducing proteins, ion channels, steroid receptors, orphan nuclear receptors, kinases, phosphatases, DNA repair enzymes, and DNA polymerases. Chemical libraries and automated screening instrumentation are emphasized, which permit rapid interrogation of optimized assays. Computational approaches and high content cell screening methodologies are employed to facilitate the identification of new chemical probes.

Primary faculty who study Drug Discovery (Click to see their detailed research profile)

Eugenia Cifuentes-Pagano
Marco Fazzari
Bruce Freeman - Cell Signaling; Redox Reactions
Yi Huang
Yu Jiang - Signaling mechanisms for cell growth control; Regulation of protein kinases and phosphatases
Patrick Pagano - Development of peptic, viral and small molecular inhibitors of NADPH oxidases and reactive species to assess NOX involvement in cardiovascular disease as well as to devise new therapies
Michael Palladino - Combined molecular and genetic approach to identify key proteins required for neural maintenance with age and understand the role of these gene products in human disease conditions.
Wei Qian
Francisco Schopfer
Shivendra Singh - The Singh laboratory focuses on preclinical and clinical investigations of novel agents derived from dietary (eg, broccoli) and medicinal plants (eg, Withania somnifera) for chemoprevention of cancers.
Ben Van Houten - Mitochondrial dysfunction in cancer and neurodegenerative diseases , structure function of DNA repair enzymes/proteins.
Nobunao Wakabayashi
Qiming Jane Wang - Targeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer.
Steven Woodcock
Kunhong Xiao
Lin Zhang - Genetic basis of differential responses to anticancer drugs and mechanisms of drug-induced apoptosis.

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