Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Bisello Lab W1313 Thomas E. Starzl Biomedical Science Tower
200 Lothrop Street, Pittsburgh, PA 15261

The general scientific theme in the laboratory is to define the role of accessory proteins (such as arrestins, caveolin, EBP50/NHERF1) in determining G protein-coupled receptor function. Our efforts focus on three areas: 1.) The signaling, trafficking and regulation of the parathyroid hormone type 1 receptor (PTH1) and its function on ion homeostasis and bone metabolism. 2.) The role of PTH1 and PTH2 receptors in vascular smooth muscle cells, with particular emphasis on their role in mitogenesis. 3.) Cellular regulation of the glucagon-like peptide 1 receptor and its role in regulating beta cell function, proliferation and survival.

Dr. Alessandro Bisello

Back to Top