Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Schopfer Lab E1316 Thomas E. Starzl Biomedical Science Tower
Pittsburgh, PA 15261

Dr. Schopfer’s research is focused on the understanding of the biological effects of electrophilic fatty acids. In particular, he studies the mechanism by which nitrated fatty acid activate and signal through peroxisome proliferator-activated receptor gamma (PPAR?).  This receptor is the target of currently used antidiabetic drugs (thiazolidinediones). The activation of the receptor regulates fat and glucose metabolism, resulting in an overall decrease of glucose levels to normal values in patients with type II diabetes. The targeting of this receptor by nitrated fatty acids results in a decrease of the glucose levels to normal values like thiazolidinediones, but without the known secondary effects exerted by thiazolidinediones. In addition to the intrinsic therapeutic value of nitrated fatty acid, they will aid in the understanding of the biological mechanism involved in PPAR? activation, leading to improved designs of anti-diabetic drugs targeting the PPAR? receptor.

Francisco J. Schopfer, PhD

Pascal Rowart, PhD

Md Fazlul Karim, PhD

Martina Steglich. Guarino, PhD

Research Staff
Sonia Salvatore

Martina Steglich

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