Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Satdarshan P. Singh Monga, MD
Professor, Pathology (Division of Experimental Pathology)
Professor of Medicine (Division of Gastroenterology, Hepatology & Nutrition)
S421 BST 200 Lothrop Street
Pittsburgh, PA 15261

Email:
smonga@pitt.edu
Phone: 412-648-9966


Education

M.D., Dayanand Medical College and Hospital, India, 1993

Photo of Satdarshan P. Singh Monga, MD

HCC is the third leading cause of death due to cancers and remains a disease with poor treatment options. A significant focus in Dr. Monga's laboratory is towards targeting this pathway and others, which are normally upregulated during liver development at the time of peak proliferation and stem cell renewal, as a novel therapeutic measure.

In addition, various animal models have been generated in Dr. Monga's laboratory, which conditionally overexpress or show lack of expression of important genes such as -catenin and others, which are in the process of being studied for the role of canonical Wnt signaling in additional liver diseases such as alcoholic liver disease, nonalcoholic fatty liver disease, glucose metaboloism and others.





Important Publications
Wagh PK, Gray JK, Zinser GM, Vasiliauskas J, James L, Monga SP, Waltz SE. beta-Catenin is required for Ron receptor-induced mammary tumorigenesis. Oncogene, 2011 Mar 21.
Thompson MD, Dar MJ, Monga SP. Pegylated interferon-alpha targets Wnt signaling by inducing nuclear export of beta-catenin. J Hepatol. 2011  Mar;54(3):506-12. Epub 2010 Oct 29 (Epub ahead of print).
Yeh TH, Krauland L, Singh V, Zou B, Devaraj P, Stolz DB, Franks J, Monga SP, Sasatomi E, Behari J. Liver-specific beta-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis. Hepatology. 2010 Oct;52(4):1410-9.
Thompson MD, Awuah P, Singh S, Monga SP. Disparate cellular basis of improved liver repair in beta-catenin overexpressing mice after long-term DDC exposure. American Journal of Pathology, 2010 Oct;177(4):1812-22.
Zhang X, Tan X, Zeng G, Misse A, Singh S, Kim Y, Klaunig J, Monga SP. Conditional -catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and PDGFR/PIK3CA signaling. Hepatology, 2010 Sep;52(3):954-65.

STUDENT NEWS


UPCOMING EVENTS
11/27/2017 8:30 AM Molecular Pharmacology Journal Club
Lloyd Harvey


11/30/2017 12:00 PM Pharmacology & Chemical Biology Seminar Series
Jeffrey L. Brodsky, Ph.D.


12/4/2017 8:30 AM Molecular Pharmacology Journal Club
Andrew Lamade


Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Molecular Pharmacology Graduate Program Ranked #2 in Faculty Scholarly Productivity Index


Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty consecutive years




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