Suite 2.6d Hillman Cancer Center
5117 Centre Avenue
Pittsburgh, PA 15213
Trinity College Dublin, Dublin, Ireland, 1998-2002
Institute for Molecular Pathology, Vienna, Austria, 2002-2006
The Salk Institute for Biological Studies, La Jolla, CA, 2006-2014
O'Sullivan Lab Website
The O’Sullivan lab at the Hillman Cancer Center conducts research into proteins that alter the structural and epigenetic functions of human telomeres. Telomeres are structures at the ends of chromosomes – the integrity of telomeres is an important factor in maintaining genome stability to prevent cancer and accelerated aging. Current efforts in the lab relate to deciphering the relationship between the regulation between chromatin structure and telomere function in the Alternative Lengthening of Telomeres pathway.
O’Sullivan RJ, Arnoult N, Lackner DH,
Oganesian L, Haggblom C, Corpet A, Almounzi G and Karlseder J. Rapid induction of the alternative lengthening of telomeres pathway by
depletion of the histone chaperone ASF1. Nat Struct Mol Biol 21:167-174, 2013.
O’Sullivan R and Karlseder J. The
great unravelling: Chromatin as a modulator of the aging process. Trends
Biochem Sci 37:466-476, 2012.
Corpet A, De Koning L, Toedling J,
Savignoni A, Berger F, Lemaitre C, O’Sullivan RJ, Karlseder J,
Barrilot E, Asselain B, Sastre-Garau X and Almouzni G. Asf1b, the
necessary Asf1 isoform for proliferation, is predictive of outcome in breast
cancer. EMBO J 30:480-493, 2011.
Flynn RL, Centore RC, O’Sullivan RJ,
Rai R, Tse A, Songyang Z, Chang S, Karlseder J and Zou L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric
single-stranded DNA. Nature 471:532-526. 2011.
O'Sullivan RJ and Karlseder J. Telomeres:
protecting chromosomes against genome instability. Nat Rev Mol Cell Biol
O’Sullivan RJ, Kubicek S, Schreiber SL
and Karlseder J. Reduced histone biosynthesis and chromatin changes
arising from a damage signal at telomeres. Nat Struct Mol Biol 17:1218-1226, 2010.
Kubicek S, O'Sullivan RJ, August EM, Hickey E,
Mechtler K, Rea S, Farina P, Homon C, Kelly T and Jenuwein T.
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone
methyltransferase. Mol Cell 25:473-481, 2007.