Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Pharmacology & Chemical Biology Seminar Series
Thursday, November 15, 2018 - 12:00 PM

“Role of trophic factors in lower urinary tract pathophysiology following spinal cord injury”

Spinal cord injury (SCI) is an extremely debilitating condition, affecting not only the mobility of an individual but also impairing the function of various internal organs. Chronic SCI-induced loss of urinary bladder control that can be life threatening at its worst (e.g. urinary tract infections and potential renal damage due to vesicoureteral reflux) and at a minimum socially debilitating.  This presentation will summarize the pathophysiology of SCI-induced lower urinary tract dysfunction and the involvement of neurotrophic factors and their cognate receptors at different stages following injury.  Our studies focus on better understanding neurotrophin signaling in the urinary bladder as it may lead to novel treatment modalities for neurogenic bladder dysfunction.

Youko Ikeda, Ph.D.
Assistant Professor
University of Pittsburgh School of Medicine

Thomas E. Starzl Biomedical Science Tower
1395 Conference Room
203 Lothrop Street
Pittsburgh PA 15213
Melanie McClain

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