Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Aaron Barchowsky, PhD
Professor, Environmental and Occupational Health
100 Technology Drive, Pittsburgh, PA 15219

Phone: 412-624-8864

BS (Zoology), North Carolina State University, Raleigh, NC, 1978.
PhD (Pharmacology), Duke University, Durham, NC, 1984.

Research Areas
Signal Transduction
Pharmacology of Cell and Organ Systems
Photo of Aaron Barchowsky, PhD

Important Publications
Barchowsky A.  Metals in Environmental Cardiovascular Disease.  In:  Issues in Toxicology 8:  Environmental Cardiology, Pollution and Heart Disease.  A Bhatnagar ed., pp. 272-300.  The Royal Society of Chemistry, Cambridge, UK, 2011.
Mossman BT, M Lippman, TW Hesterberg, KT Kelsey, A Barchowsky and JC Bonner.  Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos.  J Toxicol Environ Health B Crit Rev 14:76-121, 2011.
Liu F, A Barchowsky and PL Opresko.  The Werner Syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress.  PLoS ONE 5:e11152, 2010.
Gao F, KA Brant, RM Ward, RT Cattley, A Barchowsky and JP Fabisiak.  Multiple protein kinase pathways mediate amplified IL-6 release by human lung fibroblasts co-exposed to nickel and TLR-2 agonist, MALP-2.  Toxicol Appl Pharmacol 247:146-157, 2010.
Nemec AA, LM Zubritsky and A Barchowsky.  Chromium(VI) stimulates Fyn to initiate innate immune gene induction in human airway epithelial cells.  Chem Res Toxicol 23:396-404, 2010.
Barchowsky A.  Metals and cardiovascular disease.  In Comprehensive Toxicology 2nd edition.  CA McQueen, ed.  Volume 6, 447-463, Oxford:  Elsevier 2010.
Straub AC, LR Klei, DB Stolz and A Barchowsky.  Arsenic requires sphingosine-1 phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling.  Am J Pathol 174:1949-1958, 2009.
Nemec AA and A Barchowsky.  Signal transducer and activator of transcription 1 (STAT1) is essential for chromium silencing of gene induction in human airway epithelial cells.  Toxicol Sci 110:212-223, 2009.
Straub AC, KA Clark, MA Ross, AG Chandra, S Li, X Gao, PJ Pagano, DB Stolz and A Barchowsky.  Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide.  J Clin Invest 118:3980-3989, 2008.

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