Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Bin Wang, PhD
Adjunct Assistant Professor
1020 Locust Street, Thomas Jefferson University Medical College Jefferson Alumni Hall, Room 543
Philadelphia, PA 19107

Email:
Bin.Wang@jefferson.edu
Phone: 215-503-8226


Education

MS (Pharmacology), Anhui Medical University, Hefei, China, 1993.
PhD (Pharmacology), Anhui Medical University, Heifei, China 1999.



Research Areas
Receptor Pharmacology
Photo of Bin Wang, PhD

Dr. Wang researches parathyroid hormone receptor trafficking, interaction with NHERF1/EBP50 and other PDZ proteins, and their effects on the signaling in bone and kidney. The goal of these studies will contribute to our understanding of mineral ion homeostasis under normal conditions, as well as the pathogenesis of diseases that are related to disordered calcium and phosphorus balance in osteoporosis, chronic renal failure and hyperparathyroidism. The results will provide insights into developing drugs for selective therapeutic applications.





Important Publications
Wang B, Y Yang, L Liu, HC Blair and PA Friedman.  NHERF1 regulation of PTH-dependent biomodal pi transport in osteoblasts.  Bone 52:268-277, 2013.
Wang B, CK Means, Y Yang, T Mamonova, A Bisello, DL Altschuler, JD Scott and PA Friedman.  Ezrin-anchored PKA coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transport.  J Biol Chem 287:24148-24163, 2012.
Alonso V, CE Magyar, B Wang, A Bisello and PA Friedman.  Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting.  J Bone Miner Res 26:2923-2934, 2011.
Wang B, JA Ardura, G Romero, Y Yang, RA Hall and PA Friedman.  Na/H exchanger regulatory factors control PTH receptor signaling by facilitating differential activation of Ga protein subunits.  J Biol Chem 285:26976-26986, 2010.
Wang B, Y Yang, AB Abou-Samra and PA Friedman.  NHERF1 regulates parathyroid hormone receptor desensitization:  Interference with ß-arrestin binding.  Mol Pharm 75:1189-1197, 2009.
Wang B and Y Yang.  Generation of human PTH1R construct with Flag epitope located internally:  Comparison of two-fragment assembly by using PCR overlap extension or ligase.  J Biomol Tech 20:195-200, 2009.
Wang B, Y Yang and PA Friedman. NHERF1, a novel AKT-associating protein, regulates ERK signaling through a B-Raf mediated pathway. Mol Biol Cell 19:1637-1645, 2008.
Wang B, A Bisello, Y Yang, GG Gomero and PA Friedman . NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling. J Biol Chem 282: 26214-26222, 2007.




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