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“A Three-Wave Hypothesis of cAMP Signaling”
Pharmacology & Chemical Biology Seminar Series
2/29/2024 - 12:00 PM-1:00 PM
“A Three-Wave Hypothesis of cAMP Signaling”
Danny Altschuler, PhD
Associate Professor
Department of Pharmacology and Chemical Biology
GPCR proteins represent the most extensive class of membrane-bound receptors in mammals, playing crucial roles in cellular communication and response mechanisms. Traditionally, GPCRs are known to activate downstream effectors through G-proteins, with the Gs protein specifically stimulating adenylyl cyclase isoforms to produce the second messenger cAMP. This, in turn, initiates a range of responses both in the cytosol and the nucleus. We will discuss new findings that lay the groundwork for a new '3-wave model' that explains how the cAMP signal is transduced from the membrane to the nucleus
Thomas E. Starzl Biomedical Science Tower
1395 Conference Room
200 Lothrop St
Pittsburgh, PA 15213
Contact
Melanie Hoffner