Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Yan Xu, PhD
Professor, Anesthesiology and Structural Biology
2048 Biomedical Science Tower 3
3501 5th Ave, Pittsburgh, PA 15260

Email:
xu2@pitt.edu
Phone: 412-648-9922

Fax: 412-648-8998


Education

BS (Physics), University of Science and Technology of China, 1982 
PhD (Chemistry), State University of New York at Stony Brook, 1990 
Postdoctoral Fellow (Pharmaceutical Chemistry and Anesthesiology),University of California at San Francisco, 1990-92



Research Areas
Neuropharmacology
Photo of Yan Xu, PhD





Important Publications

Mowrey DD, MH Cheng, LT Liu, D Willenbring, W Lu, T Wymore, Y Xu and P Tang. Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels, J Am Chem Soc 135:2172−2180, 2013.

Pan JJ, Q Chen, D Willenbring, K Yoshida, T Tillman, OB Kashlan, A Cohen, XP Kong, Y Xu and P Tang.  Structure of the pentameric ligand-gated ion channel ELIC co-crystallized with its competitive antagonist acetylcholine. Nature Communications 3:714, 2012. 

Xiong W, T Cui, K Cheng, F Yang, SR Chen, D Willenbring, Y Guan, HL Pan, K Ren, Y Xu and L Zhang.  Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine 209:1121-1134, 2012.

Xiong W, KJ Cheng, T Cui, G Godlewski, KR Rice, Y Xu and L Zhang.  Cannabinoid potentiation of glycine receptors contributes to cannabis-Induced analgesia. Nat Chem Biol 7:296-303, 2011.
Xu Y, SM Liachenko, P Tang and PH Chan.  Faster recovery of cerebral perfusion in SOD1-overexpressed rats after cardiac arrest and resuscitation.  Stroke 40:2512-2518, 2009.
Hirko A, R Dallasen, S Jomura and Y Xu.  Modulation of inflammatory responses after global ischemia by transplanted umbilical-cord matrix stem cells.  Stem Cells 26:2893-2901, 2008.
Canlas C. D Ma, L Li, P Tang and Y Xu.  Structural refinement of transmembrane proteins in aligned low-q bicelles using high-resolution magic angle spinning for residual dipolar coupling measurements.  J Am Chem Soc 130:13294-13300, 2008.
Ma D, T Tillman, P Tang, E Meirovitch, R Eckenoff, A Carnini and Y Xu.  NMR studies of a channel protein without membranes:  Structure and dynamics of water-solubilized KcsA.  Proc Natl Acad Sci USA 105:16537-16542, 2008.
Jomura S, M Uy, K Mitchell, R Dallasen, C Bode and Y Xu. Potential treatment of cerebral global ischemia with umbilical cord matrix stem cells. Stem Cells 25:98-106, 2007.
Tang P and Y Xu.  Large-scale molecular dynamics simulations of general anesthetic effects on ion channel in fully hydrated membrane: Implication of molecular mechanisms of general anesthesia. Proc Natl Acad Sci USA 99:16035-16040, 2002.

STUDENT NEWS


UPCOMING EVENTS
11/27/2017 8:30 AM Molecular Pharmacology Journal Club
Lloyd Harvey


11/30/2017 12:00 PM Pharmacology & Chemical Biology Seminar Series
Jeffrey L. Brodsky, Ph.D.


12/4/2017 8:30 AM Molecular Pharmacology Journal Club
Andrew Lamade


Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Molecular Pharmacology Graduate Program Ranked #2 in Faculty Scholarly Productivity Index


Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty consecutive years




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