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University of Pittsburgh

Current Students' Publications

Ahmed Abdelnaby

Journal Articles

Yoast RE, Emrich SM, Zhang X, Xin P, Arige V, Pathak T, Benson JC, Johnson MT, Abdelnaby AE, Lakomski N, Hempel N, Han JM, Dupont G, Yule DI, Sneyd J, Trebak M. The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation. J Biol Chem. 2021 Oct;297(4):101174. doi: 10.1016/j.jbc.2021.101174. Epub 2021 Sep 6. PMID: 34499925; PMCID: PMC8496184.

Olayemi Akinyele

Journal Articles

Brignoli, T., Douglas, E., Duggan, S., Fagunloye, O. G., Adhikari, R., Aman, M. J., & Massey, R. C. (2022). Wall Teichoic Acids Facilitate the Release of Toxins from the Surface of Staphylococcus aureus. Microbiology spectrum, e0101122. Advance online publication. https://doi.org/10.1128/spectrum.01011-22
Smith, Michael and Yadav, Swara and Akinyele, Olayemi and Pels, Nana Adjoa and Horton, Daniel and Alsultan, Nashwah and Borns, Andrea and Cousin, Carolyn and Dixon, Freddie and Mann, Victoria H. and Lee, Clarence and Brindley, Paul J. and El-Sayed, Najib M. and Bridger, Joanna M. and Knight, Matty. PIWI silencing mechanism involving the retrotransposon nimbus orchestrates resistance to infection with Schistosoma mansoni in the snail vector, Biomphalaria glabrata. bioRxiv. 2021. doi:https://doi.org/10.1101/2021.01.12.426235

Wenxi An

Journal Articles

Reyes C, An W, Mo L, St Croix C, Shiva S. Nitrite inhibits mitofusin-1 degradation to attenuate vascular smooth muscle proliferation.  In Preparation (to be submitted by July 31, 2021 to Atherosclerosis, Thrombosis and Vascular Biology)

Dennis Braden

Journal Articles

Zhu D, Dai W, Srinivasan P, McClellan H, Braden D, Allee-Munoz A, Hurtado PAG, Miller LH, Duffy PE. Characterization of AMA1-RON2L complex with native gel electrophoresis and capillary isoelectric focusing  Electrophoresis. 2021 Oct 22. doi: 10.1002/elps.202000365. Online ahead of print. PMID: 34679212

Caitlyn Chapman

Journal Articles

Chapman, C. A.*, Nuwer, J. L.*, & Jacob, T. C. (2022). The yin and yang of gabaergic and glutamatergic synaptic plasticity: opposites in balance by crosstalking mechanisms. Frontiers in Synaptic Neuroscience, 14, 911020. https://doi.org/10.3389/fnsyn.2022.911020
Garrudo FFF, Mikael PE, Xia K, Silva JC, Ouyang Y, Chapman CA, Hoffman PR, Yu Y, Han X, Rodrigues CAV, Cabral JMS, Morgado J, Ferreira FC, Linhardt RJ. The effect of electrospun scaffolds on the glycosaminoglycan profile of differentiating neural stem cells. Biochimie. 2021 Mar;182:61-72. doi: 10.1016/j.biochi.2021.01.001. Epub: 2021 Jan 7.
Garrudo FFF, Mikael PE, Rodrigues CAV, Udangawa RW, Paradiso P, Chapman CA, Hoffman P, Colaço R, Cabral JMS, Morgado J, Linhardt RJ, Ferreira FC. Polyaniline-polycaprolactone fibers for neural applications: Electroconductivity enhanced by pseudo-doping. Mater Sci Eng C Mater Biol Appl. 2021 Jan;120:111680. doi: 10.1016/j.msec.2020.111680. Epub: 2020 Nov 4
Bhattacharya S, Roy I, Tice A, Chapman C, Udangawa R, Chakrapani V, Plawsky JL, Linhardt RJ. High-Conductivity and High-Capacitance Electrospun Fibers for Supercapacitor Applications. ACS Appl Mater Interfaces. 2020 Apr 29;12(17):19369-19376. doi: 10.1021/acsami.9b21696. Epub: 2020 Apr 20.
Garrudo, F.F.F.; Udangawa, R.N.; Hoffman, P.R.; Sordini, L.; Chapman, C.A.; Mikael, P.E.; Ferreira, F.A.; Silva, J.C.; Rodrigues, C.A.V.; Cabral, J.M.S.; Morgado, J.M.F.; Ferreira, F.C.; Linhardt, R.J.Polybenzimidazole nanofibers for neural stem cell culture. Materials Today Chemistry. December 2019;14. doi: 10.1016/j.mtchem.2019.08.004.

Fabliha Chowdhury

Journal Articles

Wu L., Chatla S., Lin Q., Chowdhury, F.A., Geldenhuys W., Du W. (2021). Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia. Nat Commun. 2021 https://doi: 10.1038/s41467-021-27300-w. PMID: 34836965; PMCID: PMC8626516.
Ahmed, T.; Archie, S.R.; Faruk, A.; Chowdhury, F.A.; Shoyaib, A.A.; Ahsan, C.R.Evaluation of the anti-inflammatory activities of diclofenac sodium, prednisolone and atorvastatin in combination with ascorbic acid. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry. 2020;19(3):291-301. doi: 10.2174/1871523018666190514112048.
Wu L, Li X, Lin Q, Chowdhury F, Mazumder MH, Du W. (2020). FANCD2 and HES1suppress inflammation-induced PPAR? to prevent haematopoietic stem cell exhaustion. Br J Haematol. doi: 10.1111/bjh.17230. PMID: 33222180.
Ma, Z.; Xu, J.; Wu, L.; Wang, J.; Lin, Q.; Chowdhury, F.A.; Mazumder, M.H.H.; Hu, G.; Li, X.; Du, W.Hes1 deficiency causes hematopoietic stem cell exhaustion. Stem Cells. 1 June 2020;38(6):756-768. doi: 10.1002/stem.3169.
Lin, Q., Wu, L., Ma, Z., Chowdhury, F. A., Mazumder, H. H., & Du, W. (2020). Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function. JCI Insight, 5(10). https://doi.org/10.1172/jci.insight.133365. PMID: 32434992.
Wu, L., Lin, Q., Ma, Z., Chowdhury, F. A., Mazumder, M. H. H., & Du, W. (2020). Mesenchymal PGD2 activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs. Leukemia. https://doi.org/10.1038/s41375-020-0843-8. PMID: 32366935

Aidan Cole

Journal Articles

Huang Z, Chen CW, Buj R, Tangudu NK, Fang RS, Leon KE, Dahl ES, Varner EL, von Krusenstiern E, Cole AR, Snyder NW, Aird KM. ATM inhibition drives metabolic adaptation via induction of macropinocytosis. J Cell Biol. 2023 Jan 2;222(1):e202007026. doi: 10.1083/jcb.202007026. Epub 2022 Nov 18. PMID: 36399181; PMCID: PMC9679964.

Christian Goossen

Journal Articles

Jones, S. P., Goossen, C., Lewis, S. D., Delaney, A. M., & Gleghorn, M. L. (2022). Not making the cut: Techniques to prevent RNA cleavage in structural studies of RNase-RNA complexes. Journal of Structural Biology: X, 6, 100066
Li Y, Kracun D, Dustin CM, El Massry M, Yuan S, Goossen CJ, DeVallance ER, Sahoo S, St Hilaire C, Gurkar AU, Finkel T, Straub AC, Cifuentes-Pagano E, Pagano PJ. Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42). pii: e2015666118.
Wong, N. H., Rosato, A. J., Rose, Y. M., Penix, T. S., Fung, J. B., Vanitski, A. L., Goossen, C. J., Bradshaw, S. G., Lopp, S. M., Pennington, A. D., Darmohray, V. M., Steiner, K. K., Kersey, G. E., Brylow, K. B., Pridmore, M. V., Hedges, J. S., Rynkiewicz, P., & Hudson, A. O. (2020). “Isolation and Whole-Genome Sequencing of 12 Mushroom-Associated Bacterial Strains: An Inquiry-Based Laboratory Exercise in a Genomics Course at the Rochester Institute of Technology.” Microbiology resource announcements, 9(6), e01457-19.

Robert Hall

Journal Articles

Hall R, Yuan S, Wood K, Katona M, Straub AC. Cytochrome b5 reductases: Redox regulators of cell homeostasis. J Biol Chem. 2022 Dec;298(12):102654. doi: 10.1016/j.jbc.2022.102654. Epub 2022 Oct 29. PMID: 36441026; PMCID: PMC9706631.
Carew NT, Schmidt HM, Yuan S, Galley JC, Hall R, Altmann HM, Hahn SA, Miller MP, Wood KC, Gabris B, Stapleton MC, Hartwick S, Fazzari M, Wu YL, Trebak M, Kaufman BA, McTiernan CF, Schopfer FJ, Navas P, Thibodeau PH, McNamara DM, Salama G, Straub AC. Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death. J Clin Invest. 2022 Sep 15;132(18):e147120. doi: 10.1172/JCI147120. PMID: 36106636; PMCID: PMC9479700

Trey Harkness

Journal Articles

Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022 Oct;56:102443. doi: 10.1016/j.redox.2022.102443. Epub 2022 Aug 24. PMID: 36058112; PMCID: PMC9450138.

Lisa Hong

Journal Articles

Lin CC, Mabe NW, Lin YT, Yang WH, Tang X, Hong L, Sun T, Force J, Marks JR, Yao TP, Alvarez JV, Chi JT.  RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence. Cell Death Differ. 2020 Jul;27(7):2234-2247. doi: 10.1038/s41418-020-0499-y. Epub 2020 Jan 27. PMID: 31988496
Lin CC, Mabe NW, Lin YT, Yang WH, Tang X, Hong L, Sun T, Force J, Marks JR, Yao TP, Alvarez JV, Chi JT. RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence. Cell Death Differ. 2020 Jul;27(7):2234-2247. doi: 10.1038/s41418-020-0499-y. Epub 2020 Jan 27.

Shriya Kamlapurkar

Journal Articles

Javed Z, Shin DH, Pan W, White SR, Kim YS, Elhaw AT, Kamlapurkar S, Cheng YY, Benson JC, Abdelnaby AE, Phaeton R, Wang HG, Yang S, Sullivan MLG, Watkins SC, Mullett SJ, Gelhaus SL, Lee NY, Coffman L, Aird KM, Trebak M, Karthikeyan M, Walter V, Hempel N. Alternate splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer. bioRxiv [Preprint]. 2023 Sep 20:2023.09.20.558501. doi: 10.1101/2023.09.20.558501. PMID: 37790404; PMCID: PMC10542115.

Michelle Lynskey

Journal Articles

Longarini EJ, Dauben H, Locatelli C, Wondisford AR, Smith R, Muench C, Kolvenbach A, Lynskey ML, Pope A, Bonfiglio JJ, Jurado EP, Fajka-Boja R, Colby T, Schuller M, Ahel I, Timinszky G, O'Sullivan RJ, Huet S, Matic I. Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling. Mol Cell. 2023 May 18;83(10):1743-1760.e11. doi: 10.1016/j.molcel.2023.03.027. Epub 2023 Apr 27. PMID: 37116497; PMCID: PMC10205078.
Bhargava R, Lynskey ML, O'Sullivan RJ. New twists to the ALTernative endings at telomeres. DNA Repair (Amst). 2022 Jul;115:103342. doi: 10.1016/j.dnarep.2022.103342. Epub 2022 May 13. PMID: 35588569; PMCID: PMC9675980.
Barroso-González J, García-Expósito L, Galaviz P, Lynskey ML, Allen JAM, Hoang S, Watkins SC, Pickett HA, O'Sullivan RJ. Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair. Cell Rep. 2021 Dec 7;37(10):110088. doi: 10.1016/j.celrep.2021.110088. PMID: 34879271; PMCID: PMC8724847
Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ.  Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.  Nat Struct Mol Biol. 2020 Dec;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. Epub 2020 Oct 12. PMID: 33046907  PMCID: PMC7809635
 
Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ. RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Mol Cell. 2019 Oct 3;76(1):217. doi: 10.1016/j.molcel.2019.08.009. Erratum for: Mol Cell. 2019 Oct 3;76(1):11-26.e7. PMID: 31585101; PMCID: PMC6823839
Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, de Vitis M, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ. RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Mol Cell. 2020 Jul 16;79(2):359. doi: 10.1016/j.molcel.2020.06.026. Erratum for: Mol Cell. 2019 Oct 3;76(1):11-26.e7. PMID: 32679078; PMCID: PMC7439233.
Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, de Vitis M, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ.  RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres.   Mol Cell. 2019 Oct 3;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. Epub 2019 Aug 7. PMID: 31400850  PMCID: PMC6778027
 
Kaminski N, Wondisford AR, Kwon Y, Lynskey ML, Bhargava R, Barroso-González J, García-Expósito L, He B, Xu M, Mellacheruvu D, Watkins SC, Modesti M, Miller KM, Nesvizhskii AI, Zhang H, Sung P, O'Sullivan RJ. RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. Mol Cell. 2022 Nov 3;82(21):4001-4017.e7. doi: 10.1016/j.molcel.2022.09.025. Epub 2022 Oct 19. PMID: 36265488; PMCID: PMC9713952.

Sofya Savransky

Journal Articles

Portales-Castillo I, Dean T, Cheloha RW, Creemer BA, Vilardaga JP, Savransky S, Khatri A, Jüppner H, Gardella TJ. Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome. Commun Biol. 2023 Jun 2;6(1):599. doi: 10.1038/s42003-023-04966-0. PMID: 37268817; PMCID: PMC10238420
Peña KA, White AD, Savransky S, Castillo IP, Jean-Alphonse FG, Gardella TJ, Sutkeviciute I, Vilardaga JP. Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36. J Biol Chem. 2022 Sep;298(9):102332. doi: 10.1016/j.jbc.2022.102332. Epub 2022 Aug 4. PMID: 35933010; PMCID: PMC9437850.
Langowski MD, Khan FA, Savransky S, Brown DR, Balasubramaniyam A, Harrison WB, Zou X, Beck Z, Matyas GR, Regules JA, Miller R, Soisson LA, Batchelor AH, Dutta S. Restricted valency (NPNA)n repeats and junctional epitope-based circumsporozoite protein vaccines against Plasmodium falciparum. NPJ Vaccines. 2022 Jan 27;7(1):13. doi: 10.1038/s41541-022-00430-y. Epub 2022 Jan 27.
Sutkeviciute I, Lee JY, White AD, Maria CS, Peña KA, Savransky S, Doruker P, Li H, Lei S, Kaynak B, Tu C, Clark LJ, Sanker S, Gardella TJ, Chang W, Bahar I, Vilardaga JP. Precise druggability of the PTH type 1 receptor. Nat Chem Biol. 2022 Mar;18(3):272-280. doi: 10.1038/s41589-021-00929-w. Epub 2021 Dec 23.

Abdalla Wedn

Journal Articles

Wu Y, Li Z, Wedn AM, Casey AN, Brown D, Rao SV, Omarjee S, Hooda J, Carroll JS, Gertz J, Atkinson JM, Lee AV, Oesterreich S. FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer. Mol Cancer Res. 2023 Jun 1;21(6):591-604. doi: 10.1158/1541-7786.MCR-22-0516. PMID: 36930833; PMCID: PMC10239325.

Anne Wondisford

Journal Articles

Longarini EJ, Dauben H, Locatelli C, Wondisford AR, Smith R, Muench C, Kolvenbach A, Lynskey ML, Pope A, Bonfiglio JJ, Jurado EP, Fajka-Boja R, Colby T, Schuller M, Ahel I, Timinszky G, O'Sullivan RJ, Huet S, Matic I. Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling. Mol Cell. 2023 May 18;83(10):1743-1760.e11. doi: 10.1016/j.molcel.2023.03.027. Epub 2023 Apr 27. PMID: 37116497; PMCID: PMC10205078.
Kaminski N, Wondisford AR, Known Y, Lynskey M, , Bhargava R, Barrosso-Gonzalez J, Garcia- Exposito L, He B, Xu M, Mellaharevu D, Watkins S, Modesti M, Nesvizhskii A, Zhang H, Sung P and O’Sullivan RJ. RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. Mol Cell. 2022. https://doi.org/10.1016/j.molcel.2022.09.025
 
Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I. Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Mol Cell. 2021 Jun 17;81(12):2640-2655.e8. doi: 10.1016/j.molcel.2021.04.028. PMID: 34019811; PMCID: PMC8221567.
Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ. Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol. 2020 Oct 12. doi: 10.1038/s41594-020-0512-7. PMID: 33046907 PMCID: PMC7809635