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Home > Directory > Primary Faculty > Tatiana Moiseeva, PhD

Tatiana Moiseeva, PhD

Assistant Professor
Hillman Cancer Center, Research Pavilion
Office 2.6a, 5117 Centre Avenue
Pittsburgh, PA 15232
tatiana.moiseeva@pitt.edu
Phone: 412-864-7948

Education

BSc in Physics (with honors), Saint-Petersburg State Polytechnical University, St. Petersburg, Russia, 2005
MSc in Biophysics (with honors and gold medal), Saint-Petersburg State Polytechnical University, St. Petersburg, Russia, 2007
Ph.D. in Molecular Biology, Institute of Cytology Russian Academy of Sciences, St. Petersburg, Russia, 2010
 
Headshot of Tatiana Moiseeva, PhD

Research Areas

We work on deciphering the mechanisms of the initiation of DNA replication in human cells using cell biology approaches, as well as ATR and WEE1 inhibitors. DNA replication remains one of the main targets of cancer therapies since cancer cells generally proliferate faster and are more prone to replication stress. Our main research interests are i) identifying novel replication initiation factors, ii) deciphering the non-catalytic role of DNA polymerase epsilon in the initiation of DNA replication in human cancer and non-cancer cells, iii) alterations of the replication proteins in cancers. We use auxin-inducible degron systems and split Turbo-ID proteomic screens, among other innovative methods, to identify key steps in human replication initiation that can be potential future targets for cancer therapies.    

Lab website:  https://moiseevalab.com/

 

Journal Articles

Vipat S and Moiseeva TN. The TIMELESS roles in genome stability and beyond. J Mol Biol 436(1):168206. 2024.   Invited review.
Vipat S, Gupta D, Jonchhe S, Anderspuk H, Rothenberg E and Moiseeva TN. The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells. Nature Communications 13(1):7099, 2022.
Moiseeva TN, Qian C, Sugitani N, Osmanbeyoglu HU and Bakkenist CJ.  WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells. PNAS 116(48):23891-23893, 2019.
Moiseeva TN, Yin Y, Calderon MJ, Qian C, Schamus-Haynes S, Sugitani N, Osmanbeyoglu HU, Rothenberg E,  Watkins SC and Bakkenist CJ. An ATR/Chk1 kinase dependent mechanism that suppresses dormant origin firing during unperturbed DNA replication. PNAS 116(27):13374-13383, 2019.
Moiseeva TN, Hood BL, Schamus SL, Conrads TP and Bakkenist CJ.  ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1. Nature Communications 8:1392, 2017.