Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Zhou Wang, PhD
Professor and UPMC Chair in Urological Research
Shadyside Medical Center, Suite G40
5200 Centre Ave., Pittsburgh, PA 15232

Email:
wangz2@upmc.edu
Phone: 412-623-3903

Fax: 412-623-3904


Education
BS (Biology), University of Science and Technology of China, China, 1983
PhD (Molecular Biology), University of Pittsburgh Pittsburgh, PA, 1990


Research Areas
Cancer Pharmacology
Signal Transduction
Receptor Pharmacology
Drug Discovery
Photo of Zhou Wang, PhD





Important Publications
Liu J, LE Pascal, S Isharwal, D Metzger, R Ramos Garcia, J Pilch, S Kasper, K Williams, PH Basse, JB Nelson, P Chambon and Z Wang Regenerated luminal epithelial cells are derived from pre-existing luminal epithelial cells in adult mouse prostate.  Molecular Endocrinology 25:1849,1857, 2011.
Cai L, BL Phong, A Fisher and Z Wang.  Regulation of fertility, survival and cuticle collagen function by C. elegans eaf-1 and ell-1 genes.  Journal of Biological Chemistry 286:35915-35921, 2011. 
Pascal LE, J Ai, LH Rigatti, AK Lipton, W Xiao, JR Gnarra and Z Wang.  EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate.  Angiogenesis 13:331-343, 2011.
Su F, LE Pascal, W Xiao and Z Wang.  Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via P53.  Oncogene 29:421-431, 2010.
Gupta S, Y Wang, R Ramos-Garcia, D Shevrin, JB Nelson and Z Wang.  Inhibition of 5a-reductase enhances testosterone-induced expression of U19/Eaf2 tumor suppressor during the regrowth of LNCaP xenograft tumor in nude mice.  The Prostate 70:1575-1585, 2010.
Ai J, Y Wang, JA Dar, J Liu, L Niu, J Nelson and Z Wang.  HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer.  Mol Endocrinol 23: 1963-1972, 2009.

STUDENT NEWS


UPCOMING EVENTS
11/27/2017 8:30 AM Molecular Pharmacology Journal Club
Lloyd Harvey


11/30/2017 12:00 PM Pharmacology & Chemical Biology Seminar Series
Jeffrey L. Brodsky, Ph.D.


12/4/2017 8:30 AM Molecular Pharmacology Journal Club
Andrew Lamade


Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Molecular Pharmacology Graduate Program Ranked #2 in Faculty Scholarly Productivity Index


Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty consecutive years




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