Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Pei Tang, PhD
Professor, Anesthesiology and Structural Biology
2049 Biomedical Science Tower 3
3501 5th Ave, Pittsburgh, PA 15213

Email:
ptang@pitt.edu
Phone: 412-383-9798

Fax: 412-648-9009


Education

BS (Chemistry), University of Science and Technology of China, 1982.
PhD (Chemistry), State University of New York at Stony Brook, 1990.
Postdoctoral Fellow, University of California, Berkeley Lawrence Berkeley National Lab, 1990-93



Research Areas
Neuropharmacology
Photo of Pei Tang, PhD

Dr. Tang's research interests include (1) determination of high-resolution domain structures of neuronal ion channels, such as nicotinic acetylcholine and glycine receptors; (2) characterization at the molecular level of how low-affinity drugs, particularly general anesthetics and alcohols, affect the functions of transmembrane ion channels. The approaches used in Dr. Tang's laboratory include high-resolution NMR and large-scale molecular dynamic simulations.





Important Publications
Bondarenko V, Y Xu and P Tang. Structure of the first transmembrane domain of the neuronal acetylcholine receptor b2 subunit.  Biophysical J 92:1616-1622, 2007.
Szarecka A, X Yan and P Tang.  Dynamics of heteropentameric nicotinic acetylcholine receptor:  Implications of the gating mechanism.  Proteins:  Structure, Function and Bioinformatics 68(4):948-960, 2007.
Liu Z, Y Xu Y and P Tang.  Steered molecular dynamics simulations of Na+ permeation across the gramicidin A channel.  J Phys Chem B 110:2789-12795, 2006.
Yonkunas MJ, Y Xu and P Tang. Anesthetic interaction with ketosteroid isomerase: Insights from molecular dynamics simulations. Biophysical J 89:2350-2356, 2005.
Saladino AC, Y Xu and P Tang. Homology modeling and molecular dynamics simulations of transmembrane domain structure of human neuronal nicotinic acetylcholine receptor. Biophysical J 88:1009-1017, 2005.
Liu Z, Y Xu Y and P Tang.  MD simulations of C2F6 effects on gramicidin A: Implication of mechanisms of general anesthesia. Biophysical J 88:3784-3791, 2005.




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