Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Aaron Barchowsky, PhD
Professor, Environmental and Occupational Health
332 CLMCS
100 Technology Drive, Pittsburgh, PA 15219

Email:
aab20@pitt.edu
Phone: 412-624-8864


Education
BS (Zoology), North Carolina State University, Raleigh, NC, 1978.
PhD (Pharmacology), Duke University, Durham, NC, 1984.


Research Areas
Signal Transduction
Pharmacology of Cell and Organ Systems
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Important Publications
Barchowsky A.  Metals in Environmental Cardiovascular Disease.  In:  Issues in Toxicology 8:  Environmental Cardiology, Pollution and Heart Disease.  A Bhatnagar ed., pp. 272-300.  The Royal Society of Chemistry, Cambridge, UK, 2011.
Mossman BT, M Lippman, TW Hesterberg, KT Kelsey, A Barchowsky and JC Bonner.  Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos.  J Toxicol Environ Health B Crit Rev 14:76-121, 2011.
Liu F, A Barchowsky and PL Opresko.  The Werner Syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress.  PLoS ONE 5:e11152, 2010.
Gao F, KA Brant, RM Ward, RT Cattley, A Barchowsky and JP Fabisiak.  Multiple protein kinase pathways mediate amplified IL-6 release by human lung fibroblasts co-exposed to nickel and TLR-2 agonist, MALP-2.  Toxicol Appl Pharmacol 247:146-157, 2010.
Nemec AA, LM Zubritsky and A Barchowsky.  Chromium(VI) stimulates Fyn to initiate innate immune gene induction in human airway epithelial cells.  Chem Res Toxicol 23:396-404, 2010.
Barchowsky A.  Metals and cardiovascular disease.  In Comprehensive Toxicology 2nd edition.  CA McQueen, ed.  Volume 6, 447-463, Oxford:  Elsevier 2010.
Straub AC, LR Klei, DB Stolz and A Barchowsky.  Arsenic requires sphingosine-1 phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling.  Am J Pathol 174:1949-1958, 2009.
Nemec AA and A Barchowsky.  Signal transducer and activator of transcription 1 (STAT1) is essential for chromium silencing of gene induction in human airway epithelial cells.  Toxicol Sci 110:212-223, 2009.
Straub AC, KA Clark, MA Ross, AG Chandra, S Li, X Gao, PJ Pagano, DB Stolz and A Barchowsky.  Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide.  J Clin Invest 118:3980-3989, 2008.




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