Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Freeman Lab E1314 Thomas E. Starzl Biomedical Science Tower
200 Lothrop Street, Pittsburgh, PA 15261
412-648-9671

Freeman lab

The basic investigation and clinical research activities of the Freeman Laboratory focus on the eukaryotic cell production, reactions and signal transduction properties of oxidizing and free radical inflammatory mediators (e.g., superoxide, hydrogen peroxide, nitric oxide (NO), peroxynitrite, nitrogen dioxide, oxidized/nitrated lipids).  In particular, we are interested in the actions of these species as both redox signaling mediators, as pathogenic agents in inflammatory diseases and in the case of nitro-fatty acids as drug candidates.  Our observations regarding O2 and NO-derived reactive species have lent new insight into mechanisms of redox-dependent cell signaling, post-translational protein modification and have revealed new therapeutic strategies for treating acute inflammation, metabolic syndrome, respiratory disorders and cardiovascular diseases.



Faculty
Bruce A. Freeman, PhD

Francisco J. Schopfer, PhD

Nicholas Khoo, PhD

Stacy Gelhaus Wendell, PhD

Dario Vitturi, PhD

Steven R. Woodcock, PhD

Graduate Students
Chen-Shan (Julia) Woodcock

Soma Jobbagy

Gregory Buchan

Research Staff
Lihua Li

Sonia Salvatore




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