Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Steven R. Woodcock, PhD
Research Instructor
10030 Biomedical Science Tower 3, 3501 Fifth Avenue
Pittsburgh, PA 15261

Email:
srw22@pitt.edu
Phone: 412-648-9671

Fax: 412-648-2229


Education

A.B. (Chemistry), Vassar College, Poughkeepsie, NY

M.S. (Chemistry), University of California - Irvine, Irvine, CA

Ph.D. (Organic Chemistry), University of Oregon, Eugene, OR



Research Areas
Drug Discovery
Photo of Steven R. Woodcock, PhD

Link:  Translational Program Project / Vascular Sub-Phenotypes of Lung Disease  http://www.vmi.pitt.edu/tPPG.html 


The biological convergence of reactive oxygen species, nitrate/nitrite and unsaturated lipids produce a variety of nitrated and oxidized lipids, which as redox signaling mediators have been observed to have pluripotent activity in vivo

Dr. Woodcock’s research interests include the synthesis of novel nitrated and oxidized lipids, mechanisms of nitration, and the reactivity of nitroalkenes.  We use a combination of synthetic and physical organic chemistry along with biochemistry to help identify and study these species, and to study their production and interactions with a variety of electron-rich biological molecules.  These studies support the emerging potential of nitrated lipids as therapeutic agents.

In addition we participate in collaborations with other labs to pair our synthetic interests with aspects of nitrated lipid activity in novel arenas, as well as to provide molecular probes for various redox signaling studies.  Recent projects have included isotopically labelled standards, phospholipids, nucleic acid-steroid conjugates, and fluorescent and affinity-conjugates as chemical probes.





Important Publications
Woodcock SR, SR Salvatore, G Bonacci, BA Freeman and FJ Schopfer.  Biomimetic nitration of conjugated linoleic acid:  Characterization and synthesis of naturally-occurring conjugated dienes.  J Org Chem 79:25-33, 2014.
Vitturi DA, CS Chen, SR Woodcock, N Stewart, N Wakabayashi, SR Salvatore, G Bonacci, JR Koenitzer, TW Kensler, BA Freeman and FJ Schopfer.  Modulation of nitro-fatty acid signaling:  Prostaglandin reductase-1 is a nitroalkene reductase.  J Bio Chem 288:25626-25637, 2013.
Woodcock SR, G Bonacci, SL Gelhaus and FJ Schopfer.  Nitrated fatty acids:  Synthesis and measurement.  Free Rad Biol Med 59:14-26, 2013.
Bonacci G, PR Baker, SR Salvatore, D Shores, NK Khoo, JR Koenitzer, DA Vitturi, SR Woodcock, F Golin-Bisello, MP Cole, S Watkins, C St. Croix, CI Batthyany, BA Freeman and FJ Schopfer.  Conjugated linoleic acid is a preferential substrate for fatty acid nitration.  J Biol Chem 287:44071-44082, 2012.
Rudolph V, FJ Schopfer, NK Khoo, TK Rudolph, MP Cole, SR Woodcock, G Bonacci, AL Groeger, F Golin-Bisello, CS Chen, PR Baker and BA Freeman.  Nitro-fatty acid metabolome:  Saturation, desaturation, beta-oxidation, and protein adduction.  J Biol Chem 284:1461-1473, 2009.
Woodcock SR, AJV Marwitz, P Bruno and BP Branchaud.  Synthesis of nitrolipids:  All four possible diastereomers of nitro-oleic acids:  (E)- and (Z)-, 9- and 10-Nitro-octadec-9-enoic acids.  Org Lett 8:3931-3833, 2006.




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