Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Homero Rubbo, PhD
Adjunct Professor
Dept. de Bioquimica
Avda. Gral. Flores 2125, Montevideo 11800 Uruguay

Email:
hrubbo@fmed.edu.uy
Phone: 5982 924 9561

Fax: 5982 924 9563


Education
MS (Biochemistry), University of the Republic, Uruguay.
PhD (Biochemistry), University of the Republic, Uruguay, 1993.
Photo of Homero Rubbo, PhD





Important Publications
Trostchansky A, V O’Donnell, D Goodwin, L Landino, L Marnett, R Radi and H Rubbo. Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: A free radical mechanism of inactivation. Free Rad Biol Med 42:1029-1038, 2007.
Trostchansky A, J Souza, A Ferreira, M Ferrari, F Blanco, M Trujillo, H Cerecetto, P Baker, V O’Donnell and H Rubbo.  Synthesis, isomer characterization and anti-inflammatory properties of Nitroarachidonate. Biochemistry 46:4645-4653, 2007.
Lopez GV, C Batthyány, F Blanco, H Botti, A Trostchansky, E Migliaro, R Radi, H Cerecetto and H Rubbo.  Design, synthesis and biological characterization of novel antiatherogenic Tocopherol analogs - Nitric oxide-donors. Bioorg Med Chem 13:5787-5796, 2005.
Rubbo H, R Radi, D Anselmi, M Kirk, S Barnes, J Eiserich and BA Freeman. Nitric oxide reaction with lipid peroxyl radicals spares a-tocopherol during lipid peroxidation: greater oxidant protection from the pair nitric oxide/a-tocopherol than a-tocopherol/ascorbate.  J Biol Chem 275:10812-10818, 2000.
Rubbo H, R Radi, M Trujilo, R Telleri, B Kalyanaraman, S Barnes, M Kirk and BA Freeman.  Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation:  Formation of novel nitrogen-containing oxidized lipid derivatives.  J Biol Chem 265:26066-26075, 1994.




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