Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Tatyana Mamonova, PhD
Research Instructor
W1303 Thomas E. Starzl Biomedical Science Tower
200 Lothrop Street, Pittsburgh, PA 15261

Email:
tbm7@pitt.edu
Phone: 412-383-8838

Fax: 412-648-1945


Education

M.S. (Chemistry), Al Farabi Kazak State National University, Almaty, Kazakhstan, 1986
Ph.D. (Chemistry), Kazakh National Academy of Sciences, Kazakh Scientific Research Institute of Catalysis and Electrochemistry, Almaty, Kazakhstan, 1995



Research Areas
Pharmacology of Cell and Organ Systems
Receptor Pharmacology
Photo of Tatyana Mamonova, PhD

Dr. Mamonova's research focuses on molecular modeling of the interactions of the adapter protein EBP50/ NHERF1 with its target ligands, including parathyroid hormone receptor and type II sodium-dependent phosphate co-transporters. The goal of these studies will contribute to our understanding and prediction of conformational reorganization and the structure-function relationships in NHERF1 proteins associated with the ligand binding. The results will provide insights into developing drugs for selective therapeutic applications.





Important Publications
Mamonova T, M Kurnikova and PA Friedman.  Structural basis for NHERF1 PDZ domain binding.  Biochemistry 51:3110-3120, 2012.
Mamonova T, AV Glyakina, MG Kurnikova and OV Galzitskaya.  Flexibility and mobility in mesophilic and thermophilic homologus proteins from molecular dynamics and fold unfold method.  J Bioinfo Comput Biology 8:1-18, 2010.
Mamonova T, K Speranskiy and M Kurnikova.  Interplay between structural rigidity and electrostatic interactions in the ligand binding domain of GluR2.  Proteins: Structure, Function and Bioinformatics 73:656-671, 2008.
Mamonova T, K Speranskiy and M Kurnikova.  Interplay between structural rigidity and electrostatic interations in the ligand binding domain of GluR2.  Proteins:  Structure, Function and Bioinformatics 73:656-671, 2008.
Mamonova T and M Kurnikova.  Structure and energetic of channel forming protein-polysaccaride complexes.  J Phys Chem 110:25091-25100, 2006.




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