Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Robert W. Sobol, PhD
Adjunct Professor
University of South Alabama, Mitchell Cancer Institute, 1660 Springhill Avenue
Mobile, AL 36604

Email:
rwsobol@health.southalabama.edu
Phone: 251-445-9846


Education

BS (Chemistry), Temple University, 1987. PhD (Biochemistry), Temple University Medical School, 1991. Postdoctoral Fellow, Lab. Bioch. Protéines, Univ. Montpellier II, France, 1993.



Research Areas
DNA Repair
Cancer Pharmacology
Drug Discovery
Photo of Robert W. Sobol, PhD





Important Publications
Goellner EM, B Grimme, AR Brown, Y-C Lin, X-H Wang, KF Sugrue, L Mitchell, RN Trivedi, J Tang and RW Sobol.  Overcoming temozolomide resistance in glioblastoma via dual inhibition and NAD+ biosynthesis and base excision repair.  Cancer Research 71:2308-2317, 2011.
Tang J, D Svilar, RN Trivedi, X-H Wang, EM Goellner, B Moore, RL Hamilton, LA Banze, AR Brown and RW Sobol.  N-methylpurine DNA glycosylase and DNA polymerase ß modulate BER inhibitor potentiation of glioma cells to temozolomide.  Neuro-Oncology 13:471-486, 2011.
Tang J-B, EM Goellner, X-H Wang, RN Trivedi, CM St. Croix, E Jelezcova, D Svilar, AR Brown and RW Sobol.  Bioenergetic metabolites regulate base excision repair dependent cell death in response to DNA damage.  Molecular Cancer Research 8:67-79, 2010.
Jelezcova E, RN Trivedi, X-H Wang, J-B Tang, AR Brown, EM Goellner, S Schamus, JL Fornsaglio and RW Sobol.  Parp1 activation in mouse embryonic fibroblasts promotes Pol ß-dependent cellular hypersensitivity to alkylation damage.  Mutation Research:  Fundamental and Molecular Mechanisms of Mutagenesis 686:57-67, 2010.
Trivedi RN, XH Wang, E Jelezcova, EM Goellner, J Tang and RW Sobol.  Human methyl purine DNA glycosylase and DNA polymerase ß expression collectively predict sensitivity to temozolomide.  Molecular Pharmacology 74:505-516, 2008.
Trivedi RN, KH Almeida, JL Fornsaglio, S Schamus and RW Sobol.  The role of base excision repair in the sensitivity and resistance to temozolomide mediated cell death. Cancer Research 65(14):6394-6400, 2005.




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