Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Jack Lancaster, PhD
E1344 Thomas E. Starzl Biomedical Science Tower
Pittsburgh, PA 15261

Phone: 412-383-8012

Fax: 412-648-2229


B.Sc. (Chemistry), University of Tennessee at Martin, 1970

Ph.D. (Biochemistry), University of Tennessee Center for the Health Sciences, Memphis, 1974

Research Areas
Pharmacology of Cell and Organ Systems
Redox Pharmacology
Signal Transduction
Photo of Jack Lancaster, PhD

Dr. Lancaster’s present research interests are in the chemical and physical foundations of the biological actions of reactive oxygen and nitrogen species. His most recent project is delineating the cellular functions of dinitrosyliron complexes (DNIC), which show a characteristic signal using electron  paramagnetic resonance (EPR) spectroscopy and have been observed in tissues since the 1960’s in a huge variety of pathophysiological conditions. These species contain one iron with two molecules of bound nitric oxide (NO) but the complete molecular structures of these species are essentially unknown, as are possible biological functions. We recently reported data suggesting the cellular origin of the iron and also evidence for two cellular functions, formation of protein nitrosothiols and also protection against cellular injury as a result of hypoxia-induced iron mobilization and consequent oxidative stress (Li et al. J. Biol. Chem. 2014, in press).



Important Publications
Li Q, C Li, HK Mahtani, J Du, AR Patel and JR Lancaster.  Nitrosothiol formation and protection against fenton chemistry by nitric oxide-induced dinitrosyliron complex formation from anoxia-initated cellular chelatable iron increase.  J Biol Chem 289:19917-19927, 2014.
Li Q and JR Lancaster.  Chemical foundations of hydrogen sulfide biology.  Nitric Oxide Biology and Chemistry 35:21-34, 2013.
Lancaster JR.  Protein cysteine thiol nitrosation:  Maker or marker of reactive nitrogen species-induced nonerythroid cellular signaling.  Nitric Oxide 19:68, 2008.
Lancaster JR.  Nitroxidative, nitrosative and nitrative stress:  Kinetic predictions of reactive nitrogen species chemistry under biological conditions.  Chem Res Toxicol 19:1160, 2006.
Lancaster JR.  Simulation of the diffusion and reaction of endogenously produced nitric oxide.  Proc Natl Acad Sci USA 91:8137-9141, 1994.
Reddy D, JR Lancaster and DP Cornforth.  Nitrite inhibition of Clostridium botulinum:  Electron spin resonance detection of iron-nitric oxide complexes.  Science 221:769-770, 1983.
Lancaster JR.  New biological paramagnetic center:  Octahedrally coordinated Ni(III) in the methanogenic bacteria.  Science 216:1324-1325, 1982.

Back to Top