Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Pharmacology & Chemical Biology Seminar Series
Thursday, February 07, 2019 - 12:00 PM

"The matrix and liver disease: where's the red pill?"

The extracellular matrix (ECM) not only provides structure and support for the cells in a tissue, but also acts as a reservoir for growth factors and cytokines and as a signaling mechanism by which cells can communicate with their environment and vise-versa.  Remodeling of the hepatic ECM/matrisome in response to injury is well understood (e.g., hepatic fibrosis/cirrhosis), and are considered almost synonymous with hepatic ECM changes.  However, proteomic-based studies in other organs haves demonstrated that the matrisome responses dynamically in composition after insult well before fibrotic changes to the organ.  These changes have potential to alter hepatic phenotype and function.  This presentation will discuss some of the salient processes and players involved in the ECM changes in the context of liver injury.

Gavin Arteel, PhD, FAASLD
Associate Chief for Basic Science
Pilot and Feasibility Core Director
Pittsburgh Liver Research Center
University of Pittsburgh

Thomas E. Starzl Biomedical Science Tower
1395 Conference Room
203 Lothrop Street
Pittsburgh PA 15213
Melanie McClain

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