Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Jinwoo Ahn, PhD
Assistant Professor
1055 Biomedical Science Tower 3

Phone: (412) 383-6933


Yonsei University, Seoul, Korea
B.S. 1991 in Chemistry

The Ohio State University
Ph.D., 1997 in Chemistry

Columbia University, New York
Postdoctoral Associate 1997 – 2000

Photo of Jinwoo Ahn, PhD

My research utilizes various bioanalytical and biophysical methods to investigate cellular processes at the molecular and atomic levels in relation to human disease. To that end, I utilize molecular biology and protein biochemistry to obtain functionally active recombinant protein and protein complexes, and reconstitute those processes. Investigation of protein-ligand and protein-protein interactions in important biological pathways will allow us to unravel the complex mechanisms associated with disease.

My current research focuses on investigating the molecular and structural basis of HIV/host protein-protein interactions during early states of HIV cellular infection. Specifically, we are focused on understanding mechanisms of interaction between virus structural and accessory proteins (CA, Vif, Vpr and Vpx) and respective host protein partners including Trim5-alpha, CPSF6, Apobec3G, SAMHD1 and CRL4-DCAF1 E3 ubiquitin ligases. We reconstitute events of protein-protein interaction and monitor biologically relevant outcome by using various bioanalytical and biophysical methods  including CD, fluorescence, SEC-MALS, ITC, SWAX, X-ray crystallography, NMR and HPLC as well as conventional biochemistry.

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Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Outcomes:  Time to disseration, last five graduating classes:  4.5 years, Completion Rate: 84.8%

Ranked #9 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty four consecutive years

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