Dr. Wipf’s research focuses on Total Synthesis of Natural Products - the development of new methodology, mechanistic and physical organic experiments, conformational and configurational analysis by spectroscopic and computational methods, and bio-organic and medicinal chemistry.

Organometallic Chemistry will provide most of the new revolutionary techniques for C, C and C-heteroatom bond formations and asymmetic catalysis. Dr. Wipf’s group has had a long tradition in synthetic applications of transition metals. Recently they developed the first general protocol for alkene-alkyne hetero-couplings.

His lab also is interested in the development of new stereoselctive methods for the preparation of highly functionalized heterocycles. In particular, they have developed novel protocols for five-membered heterocycle synthesis that have been widely adopted in industry and academe. Research is also conducted on Combinatorial and Solid Phase Synthesis, and Computational Prediction of Macroscopic Properties.