Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Thomas Kleyman, MD
Professor of Medicine, Cell Biology, Physiology, Chief, Renal-Electrolyte Division
A919 Scaife Hall
Pittsburgh, PA 15261

Phone: 412-647-3121

Fax: 412-648-9166

BS, Syracuse University, 1973.
MD, Washington University, 1978.
Photo of Thomas Kleyman, MD

Important Publications
Bruns JB, MD Carattino, S Sheng, AB Maarouf, OA Weisz, JM Pilewski, RP Hughey and TR Kleyman. Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma subunit. J Biol Chem 282:6153-6160, 2007.
Kashlan OB, AB Maarouf, C Kussius, RM Denshaw, KM Blumenthal and TR Kleyman. Distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel. J Biol Chem 281:30455-30462, 2006.
Carattin, MD, S Sheng, JB Bruns, JM Pilewski, RP Hughey and TR Kleyman. The epithelial Na+ channel is blocked by a peptide derived from proteolytic processing of its alpha subunit. J Biol Chem 281:18901-18907, 2006.
Morimoto T, W Liu, C Woda, MD Carattino, Y Wei, RP Hughey, G Apodaca, LM Satlin and TR Kleyman. Mechanism underlying flow-stimulation of sodium absorption in the mammalian collecting duct. Am J Physiol 291:F663-F669, 2006.
Sheng S, CJ Perry, OB Kashlan and TR Kleyman. Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels. J Biol Chem 280:8513-8522, 2005.


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Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Outcomes:  Time to disseration, last five graduating classes:  4.5 years, Completion Rate: 84.8%

Ranked #9 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty four consecutive years

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