Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Valerian Kagan, PhD
Professor and Vice Chair, Environmental and Occupational Health
333 CLMCS
100 Technology Drive, Pittsburgh, PA 15219

Email:
kagan@pitt.edu
Phone: 412-624-9479


Education

BS (Biochemistry), MV Lomonosov State University, 1967.
PhD (Biochemistry), MV Lomonosov State University, 1972.
DSc (Biochemistry, Biophysics), USSR Academy of Sciences, 1981.



Research Areas
Signal Transduction
Photo of Valerian Kagan, PhD





Important Publications
Basova LV, IV Kurnikov, L Wang, VB Ritov, NA Belikova, II Vlasova, AA Pacheco, DE Winnica, J Peterson, H Bayir, DH Waldeck and VE Kagan. Cardiolipin switch in mitochondria: Shutting off the reduction of Cytochrome c and turning on the peroxidase ectivity. Biochemistry 46(11):3423-3434, 2007.
Tyurina YY, LV Basova, NV Konduru, VA Tyurin, AI Potapovich, P Cai, H Bayir, D Stoyanovsky, BR Pitt, AA Shvedova, B Fadeel and VE Kagan. Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: Implications for the resolution of inflammation. J Biol Chem 282(11):8498-8509, 2007.
Tyurina YY, V Kini, VA Tyurin, II Vlasova, J Jiang, AA Kapralov, NA Belikova, JC Yalowich, IV Kurnikov and VE Kagan. Mechanisms of cardiolipin oxidation by cytochrome c: Relevance to pro- and antiapoptotic functions of etoposide. Mol Pharmacol 70(2):706-717, 2006.
Vlasova II, VA Tyurin, AA Kapralov, IV Kurnikov, AN Osipov, MV Potapovich, DA Stoyanovsky and VE Kagan. Nitric oxide inhibits peroxidase activity of cytochrome c.cardiolipin complex and blocks cardiolipin oxidation. J Biol Chem 281(21):14554-14562, 2006.
Kagan VE, VA Tyurin, J Jiang, YY Tyurina, VB Ritov, AA Amoscato, AN Osipov, NA Belikova, AA Kapralov, V Kini, II Vlasova, Q Zhao, M Zou, P Di, DA Svistunenko, IV Kurnikov and GG Borisenko. Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nat Chem Biol 1(4):223-232, 2005.

STUDENT NEWS


UPCOMING EVENTS
11/27/2017 8:30 AM Molecular Pharmacology Journal Club
Lloyd Harvey


11/30/2017 12:00 PM Pharmacology & Chemical Biology Seminar Series
Jeffrey L. Brodsky, Ph.D.


12/4/2017 8:30 AM Molecular Pharmacology Journal Club
Andrew Lamade


Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Molecular Pharmacology Graduate Program Ranked #2 in Faculty Scholarly Productivity Index


Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty consecutive years




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