Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Hu Lab Hillman Cancer Center Research Pavilion 2.355
5117 Centre Avenue, Pittsburgh, PA 15213
412-623-2233

 

Dr. Hu’s research focuses on understanding how posttranslational modification (PTM) of cancer-related factors—by phosphate, ubiquitin, and ubiquitin-related modifiers such as SUMO (small ubiquitin-related modifier-1)—regulates cellular process in cancer biology and treatment. Using various cellular and preclinical animal models, currently Dr. Hu is investigating the mechanistic and functional roles of phosphorylation of glycogen synthase kinase 3 (Gsk3, a key component of the Wnt/ß-catenin pathway) by tyrosine kinases in the biology of KRAS-driven pancreatic ductal adenocarcinoma (PDAC) and Wnt-driven intestinal tumorigenesis.



Faculty
Jing Hu, PhD

Fellows
Chenxi Gao, PhD




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