Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Jackson Lab 450 Bridgeside Point
Pittsburgh, PA 15213
412-648-9315

 

A major interest of the Jackson Lab is the biochemistry, molecular/cell biology, and physiology/pharmacology of adenosine.  In this regard, the Jackson Lab is investigating:

1.      Production of adenosine from the metabolism of 3’,5’-cAMP to 5’-AMP (i.e., the 3’,5’-cAMP-adenosine pathway);

2.      Production of adenosine from the metabolism of 2’,3’-cAMP to 2’-AMP and 3’-AMP (i.e., the 2’,3’-cAMP-adenosine pathway);

3.      Regulation of adenosine levels by guanosine (i.e., the guanosine-adenosine mechanism);

4.      Regulation of renal function by adenosine;

5.      Regulation of renal sympathetic neurotransmission by adenosine;

6.      Regulation vascular smooth muscle cell proliferation and glomerular mesangial cell proliferation by adenosine;

7.      Regulation of the immune system (particularly T lymphocytes) by adenosine;

8.      Regulation of inflammation by adenosine;

9.      Role of adenosine in cancer;

10.  Role of adenosine in traumatic brain injury.

Another major interest in the Jackson Lab is the regulation of arterial blood pressure and the pathophysiology of hypertension.  In this regard, the Jackson Lab is investigating:

11.  Role of adenosine in the cardiovascular system and kidneys in hypertension;

12.  Regulation of cAMP metabolism in the cardiovascular system and kidneys in hypertension;

13.  Role of RACK1 (Receptor for Activated C Kinase 1) in the cardiovascular system and kidneys in hypertension;

14.  Role of dipeptidyl peptidase IV in the cardiovascular system and kidneys in hypertension.

15.  Cross talk between G-protein signal transduction pathways in the cardiovascular system and kidneys in hypertension.

 



Faculty
Edwin K. Jackson, PhD

Fellows
Elizaveta Menchikova, PhD

Research Staff
Shawn Kotermanski

Delbert Gillespie, Jr

Zaichuan Mi




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