Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Pharmacology of Cell and Organ Systems
Investigators in the Molecular Pharmacology program are also examining the mechanisms of autonomic synaptic transmission and the autonomic regulation of the urogenital and renal systems. These studies include: 1) neuroanatomical and neurophysiological research aimed towards the development of agents to modulate neuronal control of the urinary bladder, colon, and sex organs; 2) biochemical/molecular analysis of the role of PP-fold peptides released from autonomic synaptic junctions in the regulation of renovascular tone and arterial blood pressure in genetic hypertension; and 3) the interaction between the sympathetic nervous system and estradiol on renal function.

Graduate faculty who study Pharmacology of Cell and Organ Systems (Click to see their detailed research profile)

Aaron Barchowsky - The main focus of the research in the Barchowsky laboratory is the cellular and molecular mechanisms for pathogenic tissue remodeling and metabolic dysfunction caused by environmental metals exposures. The core theme of the research has been on metal stimulated redox biology and discoveries over the past 30 years include demonstration of environmental arsenic exposures stimulating vascular angiogenesis and remodeling through G-protein-coupled receptor activation of NADPH Oxidases. Current studies focus on mechanisms through which arsenic or aging promote mitochondrial maladaptive responses that pathologically reprogram epigenetic regulation of skeletal muscle stem cell fate, tissue regeneration, and metabolism.
Hülya Bayir - Dr. Hülya Bayir’s research focuses on the primary themes of mitochondrial injury and oxidative signaling. She has organized a multidisciplinary team of investigators to study novel approaches to the treatment of mitochondrial dysfunction by targeting lipid oxidation. Her laboratory integrates the work of clinical and basic science researchers.
Robert Binder - Tumor immunology; Heat Shock Protein Immunobiology; Tumor immunosurveillance; biology of scavenger receptors in antigen crosspresentation; immune responses initiated by endogenous molecules.
Lori Birder - Study a number of ion channel/receptor targets within the bladder epithelium and the possible role of the urothelium in urinary bladder function.
Alessandro Bisello - Structure, signalling and trafficking of G-protein-coupled receptors. Role of EBP50 in vascular remodeling and role of GLP-1 in pancreatic beata cell function.
William de Groat - Study of the autonomic mechanisms involved in the control of urogenital function. Study of visceral pain mechanisms.
Donald DeFranco - Glucocorticoids and Neurodevelopment. Prostate cancer.
Peter Friedman - Parathyroid hormone receptor trafficking, regulation, signaling.
Edwin Jackson - The physiology and pharmacology of endogenous modulators of growth, structure and function of cells in the heart, blood vessels and kidneys, with particular focus on adenosine, the renin-angiotensin soystem and estradiol metabolites.
Anthony Kanai - Roles of the urothelium, interstitial cells and afferent nerves in urinary incontinence--studied using optical mapping. Nitric oxide in radiation cystitis and the mitochondrial targeting of radioprotectants.
Adrian Lee
Michael Lotze - Tumor immunology; dendritic cell biology; cytokine biology; regulation of apoptosis in immune effectors; role of the nuclear protein HMGB 1 in promoting inflammation, mRNA role in regulating the translation of proteins in macrophages and other inflammatory cells; autophagy.
Carola Neumann
Steffi Oesterreich - Molecular mechanism and clinical relevance of endocrine response in breast cancer
Patrick Pagano - Development of peptic, viral and small molecular inhibitors of NADPH oxidases and reactive species to assess NOX involvement in cardiovascular disease as well as to devise new therapies
Michael Palladino - Combined molecular and genetic approach to identify key proteins required for neural maintenance with age and understand the role of these gene products in human disease conditions.
Guillermo Romero - Regulation of G-protein coupled receptor function by phospholipase D and PDZ proteins; molecular regulation of Wnt signaling. Signal Transduction mechanisms associated to the activation of cellular phospholipases.
Francisco Schopfer
Sruti Shiva - The mechanisms by which reactive nitrogen species regulate mitochondrial function and signaling, particularly in conditions of hypoxia or ischemia.
Adam Straub - Redox signaling mechanisms in the microcirculation.
Ben Van Houten - Mitochondrial dysfunction in cancer and neurodegenerative diseases , structure function of DNA repair enzymes/proteins.
Jean-Pierre Vilardaga - Understanding molecular mechanisms of G protein-coupled receptor(GPCR) signalling and trafficking.
Qiming Jane Wang - Targeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer.
Wen Xie - Nuclear hormone receptor-mediated gene regulation in endrocrinology, gastroenterology, and cancer. Nuclear hormone receptors as therapeutic targets for metabolic syndrome.

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings


Time to dissertation Defense
, last five graduating classes:  4.6 years, Completion Rate: 86.49%

First Author Publications (All students, past 5 year mean):  2.03;   Total Publications: 5.10

F-series Grants (F30/F31) (All Students, past 5 year mean):  12/34 (35%) 

Ranked #9 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty-four consecutive years

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