Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Adrian D. Sculptoreanu, PhD
Adjunct Assistant Professor
Departments of Molecular Physiology & Biophysics University of Iowa
Iowa City, IA 52242

Email:
ads5@pitt.edu
Phone: 319-779-1443


Education

BSc (Neurophysiology), Carleton University, Ottawa, Ontario, 1982.
PhD (Physiology), Duke University, 1983.
MSc (Cardiac Physiology), Carleton University, Ottawa, Ontario, 1987.
PhD (Biophysics), Universtiy de Sherbrooke, 1991.



Research Areas
Pharmacology of Cell and Organ Systems
Photo of Adrian D. Sculptoreanu, PhD





Important Publications
Sculptoreanu A, FA Kullman DE Artim, FA Bazley, F Schopfer, S Woodcock, BA Freeman and WC de Groat.  Nitro-oleic acid inhibits firing and activates TRPV1- and TRPA1-mediated inward currents in DRG neurons from adult male rats.  J Pharmacol Exp Ther 2010 Mar 22 [Epub ahead of print], 2010.
Sculptoreanu A, DE Artim and WC de Groat.  Neurokinins inhibit low threshold inactivating K+ currents in capsaicin responsive DRG neurons.  Exp Neurol 219:562-573, 2009.
Sculptoreanu A, AF Kullmann and WC de Groat.  Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats.  Eur J Neurosci 27:3171-3181, 2008.
Srinivasan R, D Wolfe, J Goss, S Watkins, WC de Groat, A Sculptoreanu and JC Glorioso.  PKCe contributes to basal and sensitizing responses of TRPV1 to capsaicin in dorsal root ganglion neurons.  Eur J Neurosci 28:1241-1254, 2008.
Sculptoreanu A and WC de Groat.  Neurokinins enhance excitability in capsaicin-responsive DRG neurons.  Exp Neurol 205:92-100, 2007.
Yamane H, WC de Groat and A Sculptoreanu.  Effects of ralfinamide, a Na+ channel blocker, on firing properties of nociceptive dorsal root ganglion neurons of adult rats.  Exp Neurol 208:63-72, 2007.
Srinivasan R, S Huang, S Chaudhry, A Sculptoreanu, D Krisky, M Cascio, PA Friedman, WC de Groat, D Wolfe and JC Glorioso.  An HSV vector system for selection of ligand-gated ion channel modulators.  Nat Methods 4:733-739, 2007.




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