Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Pharmacology & Chemical Biology Seminar Series
Thursday, February 28, 2019 - 12:00 PM

"Cellular Communication via Adhesion"

Adhesion G Protein-Coupled Receptors (GPCRs) are cell adhesion proteins that mediate cellular communication and play critical roles in embryonic and neural development. However, their mechanisms of action remain poorly understood. In the past several years, three-dimensional structures of adhesion GPCRs and their ligands have been reported at atomic resolutions and revealed distinct protein folds and unique structural features. In this talk, we will discuss these structures which, together with structure-guided biochemical and functional analyses, provide hints for the mechanisms of trans-cellular communication at the synapse and other cell-cell contact sites.


Demet Arac, PhD
Assistant Professor
Department of Biochemistry and Molecular Biology
University of Chicago

Thomas E. Starzl Biomedical Science Tower
1395 Conference Room
203 Lothrop Street
Pittsburgh PA 15213
Melanie McClain

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