Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Mark T. Gladwin, MD
Distinguished Professor; Division Chief, PACCM and Director, Vascular Medicine Institute
E1244 Biomedical Science Tower
Pittsburgh, PA 15261

Email:
gladwinmt@upmc.edu
Phone: 412-624-8725

Fax: 412-648-5980


Education

MD, University of Miami Honors Program in Medical Education, 1991

Photo of Mark T. Gladwin, MD

Since 1998, Dr. Gladwin's research activities have led to four scientific discoveries resulting in more than 150 published peer-reviewed manuscripts, 25 approved human subject protocols, and more than 1,000 patient protocol enrollments at the NIH Clinical Center, during Dr. Gladwin's Tenure as an NIH Branch Chief.

(1) The discovery that the nitrite anion is a circulating storage pool for NO bioactive (Gladwin, et al. PNAS 2000) that regulates hypoxic vasodilation (Cosby Nature Medicine 2003) and the cellular resilience to low oxygen and ischemia (Duranski JCI 2005).

(2) The discovery of a novel physiological function for hemoglobin as an eletronically and allosterically-regulated nitrite reductase (Cosby, et al. nature Medicine 2003; Huang et al. JCI 2005).

(3) The characterization of a novel mechanism of disease, hemolysis-associated endothelial dysfunction (Reiter, et al. Nature Medicine 2002; Morris et al. JAMA 2005; Minneci et al. JCI 2005; Rother et al. JAMA 2005).

(4) The mechanistic, clinical, and epidemiological description of a human disease syndrome, hemolysis-associated pulmonary hypertension (Gladwin, et al. NEJM 2004).





Important Publications
Suzuki YJ, Steinhorn RH, Gladwin MT. Antioxidant therapy for the treatment of pulmonary hypertension. Antioxid Redox Signal 2013 Jan 20.
Solomon SB, Wang D, Sun J, Kanias T, Feng J, Helms CC, Solomon MA, Alimchandani M, Quezado M, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood, 2012 Dec 18.
George MP, Champion HC, Simon M, Guyach S, Tarantelli R, Kling HM, Brower A, Janssen C, Murphy J, Carney JP, Morris A, Gladwin MT, Norris KA. Physiologic changes in a non-human primate model of HIV-associated pulmonary arteiral hypertension. Am J Respir Cell Mol Biol. 2012 Dec 13. [Epub ahead of print]
Gladwin MT, Kim-Shapiro DB. Vascular biology: Nitric oxide caught in traffic. Nature. 2012 Nov 15;491(7424):344-5. doi: 10.1038/nature11640. Epub 2012 Oct 31. No abstract available.
Okamoto T, Tang X, Janocha A, Farver CF, Gladwin MT, McCurry KR. Nebulized nitrite protects rat lung grafts from ischemia reperfusion injury. J. Thorac Cardiovasc Surg. 2012 Nov 8. doi:pii: S0022-5223(12)00459-X. 10.1016/j.jtcvs.2012.04.006. [Epub ahead of print]
Solomon SB, Bellavia L, Sweeney D, Piknova B, Perlegas A, Helms CC, Ferreyra GA, Bruce King S, Raat NJ, Kern SJ, Sun J, McPhail LC, Schechter AN, Natanson C, Gladwin MT, Kim-Shapiro DB. Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin. Free Radic Biol Med. 2012 Oct 23;53(12):2229-2239. doi: 10.1016/j.freeradbiomed.2012.10.548. [Epub ahead of print]




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