Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Thanos Tzounopoulos, PhD
Associate Professor, Otolaryngology
10021 BST 3
Pittsburgh, PA 15261

Email:
thanos@pitt.edu
Phone: 412-383-8626


Education
B.S. (Biology) University of Athens, 1992
Ph.D. (Molecular Biology & Physiology) Oregon Health and Science University, 1997
Postdoctoral Fellow (Physiology) University of California-San Francisco, 1997-2000
Postdoctoral Fellow Oregon Hearing Research Center, Vollum Institute, 2000-2002
Postdoctoral Fellow Oregon Hearing Research Center, Vollum Institute, April 2002-2006
Photo of Thanos Tzounopoulos, PhD

(Dr. Tzounopoulos's on the Auditory Research Group website)

Mechanisms of synaptic plasticity have traditionally be ascribed to higher-order sensory processing areas such as the cortex, whereas early sensory processing centers have been considered largely hard-wired. However, recent results from our lab and human studies have revealed remarkable evidence for cellular and behavioral mechanisms for learning and memory in early stages of sensory processing. We are investigating the cellular mechanisms underlying synaptic and intrinsic plasticity in sensory systems and in their role for normal and pathological sensory processing.

A second area of our research focuses on tinnitus and its underlying cellular mechanisms. The nervous system is plastic; expression of neural plasticity can lead to compensation for loss of function and adaptaion to changing demands. However, plasticity-induced changes can also cause signs and symptoms of disease, such as tinnitus. our goal is to understand the maladaptive plasticity mechanisms underlying the development and the establishment of tinnitus.

Thanos Tzounopoulos and his associates employ eletrophysiological, imaging and behavioral approaches to answer these questions.




Important Publications
Middleton, J.W., Kiritani, T., Pedersen, C., Turner, J., Shepherd, G.M.G. and Tzounopoulos, T. Mice with Behavioral Evidence of Tinnitus Exhibit Dorsal Cochlear Nucleus Hyperactivity Due to Decreases GABAergic Inhibition. Proc Natl Acad Sci U S A (2011, In Press)
Zhao, Y. and Tzounopoulos, T. Physiological Activation of Cholinergic Inputs Controls Associative Synaptic Plasticity via Modulation of Endocannabinoid Signaling. J. of Neuroscience Mar 2;31(9): 3158-68, 2011.
Tzounopoulos, T. and Kraus, N. Learning to Encode Timing: Mechanisms of Plasticity in the Auditory Brainstem. Neuron, May 28; 62(4): 463-9, 2009.
Zhao, Y., Rubio, M. and Tzounopoulos, T. Distince Functional and Anatomical Architecture of Endocannabinoid System in the Auditory Brainstem. J Neurophysiol 101: 2434-2446, 2009
Tzounopoulos, T., Rubio, M., Keen, J. and Trussell, L. Coactivation of Pre- and Postsynaptic Signaling Mechanisms Determines Cell-specific Spike Timing-Dependent Plasticity. Neuron, 54, 291-301, 2007.
Tzounopoulos, T., Kim, Y., Oertel, D. and Trussell, L. Cell-specific, Spike Timing Dependent Plasticities in the Dorsal Cochlear Nucleus. Nature Neuroscience, 7, 719-725, 2004




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