Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Christopher Bakkenist, PhD
Associate Professor, Radiation Oncology
Hillman Cancer Center 2.6
5117 Centre Avenue, Pittsburgh, PA 15232

Email:
cjb38@pitt.edu
Phone: 412-623-7765

Fax: 412-623-7761


Education

BSc (Hons), Biochemistry/Chemistry, University of Liverpool, UK, 1989. PhD Imperial College, University of London, UK, 1994. Postdoctoral Fellow, St. Jude Children's Research Hospital, Memphis, TN, 1999-2005.



Research Areas
Cancer Pharmacology
DNA Repair
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Important Publications
Choi S, Srivas R, Fu KY, Hood BL, Dost B, Gibson GA, Watkins SC, Van Houten B, Bandeira N, Conrads TP, Ideker T and Bakkenist CJ.  (2012) Quantitative proteomics reveals ATM kinase-dependent exchange in DNA damage response complexes.  Journal of Proteome Research, advance online publication
Gamper AM, Choi S, Matsumoto M, Banerjee D, Tomkinson AE and Bakkenist CJ.  (2012)  ATM physically and functionally interacts with PCNA to regulate DNA synthesis.  Journal of Biological Chemistry 287:12445-12454.
Choi S, Toledo LI, Fernandez-Capetillo O and Bakkenist CJ.  (2011)  CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.  DNA Repair 10:1000-1001
White JS, Yue N, Hu J, Bakkenist CJ.  (2011)  The ATM kinase signaling induced by the low-energy ß-particles emitted by 33P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic ß-particles emitted by 32P.  Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 708, 28-36

Choi S, Gamper A, White JS, Bakkenist CJ.  (2010)  Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle 9: 4052-4057

White JS, Choi S, Bakkenist CJ.  (2010)  Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.  Science Signaling 3: ra44

Bakkenist CJ, Kastan MB.  (2004)  Initiating Cellular Stress Responses. Cell 118: 9-17

Bakkenist CJ, Kastan MB.  (2003)  DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.  Nature 421: 499-506





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