Pharmacology of Cell and Organ Systems Investigators in the Molecular Pharmacology program are also examining the mechanisms of autonomic synaptic transmission and the autonomic regulation of the urogenital and renal systems. These studies include: 1) neuroanatomical and neurophysiological research aimed towards the development of agents to modulate neuronal control of the urinary bladder, colon, and sex organs; 2) biochemical/molecular analysis of the role of PP-fold peptides released from autonomic synaptic junctions in the regulation of renovascular tone and arterial blood pressure in genetic hypertension; and 3) the interaction between the sympathetic nervous system and estradiol on renal function. Faculty Beckel, Jonathan Associate Professor & Vice Chair for Medical EducationMolecular, cellular and physiological approaches to understand epithelial-afferent nerve interactions and how changes in this communication play a role in bladder pathology jmbeckel@pitt.edu 412-383-5004 Bisello, Alessandro Professor & Vice Chair for Experiential LearningStructure, signaling and trafficking of G-protein-coupled receptors. Role of EBP50 in vascular remodeling and role of GLP-1 in pancreatic beata cell function. alb138@pitt.edu 412-648-7347 Chang, Fei Research Instructor fec29@pitt.edu 530-219-1806 Cifuentes Pagano, Eugenia Research Assistant Professor mec110@pitt.edu 412-648-2610 de Groat, William Distinguished Professor Study of the autonomic mechanisms involved in the control of urogenital function. Study of visceral pain mechanisms. wcd2@pitt.edu 412-648-9357 DeFranco, Donald Professor & Executive Vice Chair, Associate Dean for Medical Student ResearchGlucocorticoids and Neurodevelopment. Prostate cancer. dod1@pitt.edu 412-624-4259 Friedman, Peter ProfessorParathyroid hormone receptor trafficking, regulation, signaling. paf10@pitt.edu 412-383-7783 Jackson, Edwin Distinguished Professor The physiology and pharmacology of endogenous modulators of growth, structure and function of cells in the heart, blood vessels and kidneys, with particular focus on adenosine, the renin-angiotensin system and estradiol metabolites. edj@pitt.edu 412-648-1505 Lee, Adrian Professor; Pittsburgh Foundation Chair in Precision Medicine leeav@upmc.edu 412-641-7557 Neumann, Carola Associate Professor & Vice Chair for Precision and Translational Pharmacology can44@pitt.edu 412-641-7725 Oesterreich, Steffi Professor, The Shear Family Foundation Chair in Breast Cancer ResearchMolecular mechanism and clinical relevance of endocrine response in breast cancer oesterreichs@upmc.edu 412-641-8555 Pagano, Patrick Professor; Assistant Dean for Graduate StudiesDevelopment of peptic, viral and small molecular inhibitors of NADPH oxidases and reactive species to assess NOX involvement in cardiovascular disease as well as to devise new therapies pagano@pitt.edu 412-383-6505 Palladino, Michael Professor & Vice Chair for Faculty AffairsCombined molecular and genetic approaches to identify key proteins required for neural maintenance with age and understand the role of these gene products in metabolic disease conditions mjp44@pitt.edu 412-383-5900 Pena, Karina Research Instructor kapena@pitt.edu 412-383-8831 Romero, Guillermo Associate ProfessorRegulation of G-protein coupled receptor function by phospholipase D and PDZ proteins; molecular regulation of Wnt signaling. Signal Transduction mechanisms associated to the activation of cellular phospholipases. ggr@pitt.edu 412-648-9408 Schopfer, Francisco Professor & Vice Chair for Biotechnology Development fjs2@pitt.edu 412-648-0193 Shiva, Sruti Professor & Vice Chair for Academics and Equity Associate Director, Vascular Medicine InstituteThe mechanisms by which reactive nitrogen species regulate mitochondrial function and signaling, particularly in conditions of hypoxia or ischemia. sss43@pitt.edu 412-383-5854 Stabile, Laura Research Associate Professor stabilela@upmc.edu 412-623-2015 Straub, Adam Professor & Vice Chair, Research; Assistant Dean of Basic Sciences Faculty AffairsRedox signaling mechanisms in the microcirculation. astraub@pitt.edu 412-648-2790 Trebak, Mohamed Professor trebakm@pitt.edu 412-648-1381 Van Houten, Ben ProfessorMitochondrial dysfunction in cancer and neurodegenerative diseases , structure function of DNA repair enzymes/proteins. vanhoutenb@upmc.edu 412-623-7762 Vilardaga, Jean-Pierre ProfessorUnderstanding molecular mechanisms of G protein-coupled receptor (GPCR) signaling and trafficking. jpv@pitt.edu 412-648-2055 Volonte, Daniela Research Assistant Professor dav18@pitt.edu 412-624-1006 Wang, Qiming Jane ProfessorTargeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer. qjw1@pitt.edu 412-383-7754