Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Recent Student Publications


Student Publications - 2017 and 2018


Joshua Lorenz - Guertin - 2018
Joshua M. Lorenz-Guertin, Matthew J. Bambino and Tija C. Jacob* 2018, γ2 GABAAR Trafficking and the Consequences of Human Genetic Variation  Front. Cell. Neurosci., 23 August 2018 | https://doi.org/10.3389/fncel.2018.00265

Ravi Patel - 2018
Weir MC, Shu ST, Hellwig S, Patel R, Chen L, Tan L, Liu Y, Gray NS, Smithgall TE. 2018, Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo.  ACS Chem Biol. 2018 Jun 15;13(6):1551-1559  PMID: 29763550
 

Joshua Lorenz - Guertin - 2018
Ye J, Das S, Roy A, Wei W, Huang H, Lorenz-Guertin JM, Zhang Z, Xu Q, Jacob TC, Wang B, Sun D, Wang QJ. Ischemic injury-induced CaMKIIδ and CaMKIIγ confer neuroprotection through the NF-κB signaling pathway. (June 2018 accepted in Mol Neurobiol).

Nicole Kaminski - 2018
Kaminski, N.A. and Wong, E.A. (2018) Differential mRNA expression of nutrient transporters in male and female chickens. Poultry Science, (97)1: 313–318, https://doi.org/10.3382/ps/pex262
 

Ryan Staudt - 2017
Moroco JA, Alvarado JJ, Staudt RP, Shi H, Wales TE, Smithgall TE, 2018 Engen JR. Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding. J Mol Biol. 2018 Feb 2;430(3):310-321. doi: 10.1016/j.jmb.2017.12.008. Epub 2017 Dec 16. PMID: 29258818 PMCID: PMC5801098

Joshua Lorenz - Guertin - 2017
Brady ML, Pilli J, Lorenz-Guertin JM, Das S, Moon CE, Graff N, Jacob TC. 2018, Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling. Neuropharmacology. 2018 Jan;128:324-339. doi: 10.1016/j.neuropharm.2017.10.022. Epub 2017 Oct 23. PMID: 29074304 PMCID: PMC5739058

Joshua Lorenz - Guertin - 2017
Lorenz-Guertin JM, Wilcox MR, Zhang M, Larsen MB, Pilli J, Schmidt BF, Bruchez MP, Johnson JW, Waggoner AS, Watkins SC, Jacob TC. 2017,  A versatile optical tool for studying synaptic GABAA receptor trafficking. J Cell Sci. 2017 Nov 15;130(22):3933-3945. doi: 10.1242/jcs.205286. Epub 2017 Oct 12. PMID:     29025969 PMCID: PMC5702044

Victoria Veroli - 2017

Munguía B., Teixeira R., Veroli V., Melian E., Saldaña J., Minteguiaga M., Señorale M., Marín M., Domínguez L. “Purification of native M. vogae and H. contortus tubulin by TOG affinity chromatography” Experimental Parasitology. 182:37-44, 2017.


Alex White - 2017

Dube, S.; Dube, H.; Green, N.B.; Larsen, E.M.; White, A.; et al. In vivo delivery and activation of masked fluorogenic hydrolase substrates by endogenous hydrolases in C. elegans. ChemBioChem. 2017 Sep 19; 18(18): 1807-1813. doi: 10.1002/cbic.201700278. Epub 2017 Aug 7.PMCID:PMC5605452


Atinuke Dosunmu-Ogunbi - 2017

Kulkarni, S., Dolezal, J. M., Wang, H., Jackson, L., Lu, J., Frodey, B. P., Dosunmu-Ogunbi A, Li Y., Fromherz M., Kang A., Santana-Santos L., Benos P., Prochownik, E. V. (2017). Ribosomopathy-like properties of murine and human cancers. PLoS ONE12(8)PMCID: PMC5562309
 


Joseph Galley - 2017
Alvarez RA, Miller MP, Hahn SA, Galley JC, Bauer E, Bachman T, Hu J, Sembrat J, Goncharova D, Mora AL, Rojas M, Goncharova E, Straub AC. Targeting pulmonary endothelial hemoglobin α improves nitric oxide signaling and reverses pulmonary artery endothelial dysfunction. Am J Respir Cell Mol Biol. 2017; Aug 11.
 

Nolan Carew - 2017
Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty CJ, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC. Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling. Circ Res. 2017 Jul 7;121(2):137-148. doi: 10.1161/CIRCRESAHA.117.310705. Epub 2017 Jun 5. PMID: 28584062 PMCID: PMC5527687
 

Lloyd Harvey - 2017

Harvey LD, Chan SY. Emerging metabolic therapies in pulmonary arterial hypertension. J Clin Med. 2017;6(4). PubMed PMID: 28375184; PubMed Central PMCID: PMC5406775.


Joshua Lorenz - Guertin - 2017
Lorenz-Guertin JM, Jacob TC.  2018, GABA type a receptor trafficking and the architecture of synaptic inhibition. Dev Neurobiol. 2018 Mar;78(3):238-270. doi: 10.1002/dneu.22536. Epub 2017 Sep 19. Review. PMID 28901728

Thong Luong - 2017

Egnatchik RA, Brittain EL, Shah AT, Fares WH, Ford HJ, Monahan K, Kang CJ, Kocurek EG, Zhu S, Luong T, Nguyen TT, Hysinger E, Austin ED, Skala MC, Young JD, Roberts LJ 2nd, Hemnes AR, West J, Fessel JP. Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension. Pulm Circ. 2017 Feb 1;7(1):186-199. doi: 10.1086/690236. eCollection 2017 Mar. PubMed PMID: 28680578; PubMed Central PMCID: PMC5448547.


Thong Luong - 2017

Hardeman KN, Peng C, Paudel BB, Meyer CT, Luong T, Tyson DR, Young JD, Quaranta V, Fessel JP. Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition. Sci Rep. 2017 Feb 16;7:42604. doi: 10.1038/srep42604. PubMed PMID: 28205616; PubMed Central PMCID: PMC5311997.


Nicholas Todd - 2017
Huang Y., Todd N., Thathiah A. 2017, The role of GPCRs in neurodegenerative diseases: avenues for therapeutic intervention.  Curr Opin Pharmacol. 2017 Feb;32:96-110. doi: 10.1016/j.coph.2017.02.001. Epub 2017 Mar 10. PMID: 28288370
STUDENT NEWS


UPCOMING EVENTS
12/13/2018 10:45 AM Molecular Pharmacology Journal Club
Song-My Hoang


12/13/2018 12:00 PM Pharmacology & Chemical Biology Seminar Series
Chris Bakkenist, Ph.D.


12/17/2018 12:00 PM Pharmacology & Chemical Biology Special Seminar
Ethel R. Pereira, PhD


Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty two consecutive years




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