Department of Pharmacology & Chemical Biology at the University of Pittsburgh
James Perel, MD
Professor Emeritus of Psychiatry

Phone: 412-246-6600

Fax: 412-246-6610

BS (Chemistry), City College of New York, 1956.
MS (Chemistry), New York University, 1961.
PhD (Physical/Organic chemistry), New York University, 1964.
Postdoctoral fellowship in Clinical/Chemical Pharmacology, NYU and NIGMS, 1963-1965.
Photo of James Perel, MD

The mechanisms of psychotropic drug actions are being investigated with regards to PK/PD, stereoselectiviy of drug metabolism pathways, pharmacogenetics and pathways of Cytochromes actions, and prediction of ultimate individual response of special populations via biomarker and pharmacogenetic profiling of antidepressants.The approach is translational i.e. from laboratory findings to clinical assessments from adaptively designed concentration-controlled clinical trials. Among the agents under current investigation are: Bupropion,SSRIs and third-generation antidepressants, atypical antipsychotics and more recently introduced mood stabilizers.

Important Publications
Perel JM, WB Daviss and GR Rudolph. Comparative stereoselectivity of the conversions of bupropion to neurochemically active metabolites by CYP 2B-6 and 3A-4. Ther Drug Monit, in press, 2007.
Daviss WB, JM Perel, DA Brent, DA Axelson, GR Rudolph, R Gilchrist, S Nuss and B Birmaher.  Acute antidepressant response and plasma levels of bupropion and metabolites in a pediatric-aged sample: An exploratory study. Ther Drug Monit 28:190-198, 2006.
Axelson DA, JM Perel, B Birmaher, GR Rudolph, S Nuss, L Yurasits, J Bridge and D Brent . Platelet serotonin reuptake inhibition and response to SSRIs in depressed adolescents. Am J Psychiat 162:802-804, 2005.
Perel JM and MW Jann. Antipsychotics.  In: Applied Pharmacokinetics and Pharmacodynamics, Vol. 4, 813-838, 2005.
Perel JM, D Thai and GR Rudolph. Comparisons among clinical PK/PD of threo-d-methylphenidate and d-analogues. Clin Pharmacol Ther 71:(2), 2002.

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